ArticleJournal of endocrinology, diabetes & obesity
Nutritional Supplementation with Essential Amino Acids and Phytosterols May Reduce Risk for Metabolic Syndrome and Cardiovascular Disease in Overweight Individuals with Mild Hyperlipidemia.
Article in Journal of endocrinology, diabetes & obesity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Associations of the SLCO1B1 Polymorphisms With Hepatic Function, Baseline Lipid Levels, and Lipid-lowering Response to Simvastatin in Patients With Hyperlipidemia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- Dietary proteins, amino acids and insulin resistance: a mini review.Frontiers in nutrition · 2025Review
- Consideration of the role of protein quality in determining dietary protein recommendations.Frontiers in nutrition · 2024Review
- International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance.Journal of the International Society of Sports Nutrition · 2023Article
- Amino acid intake with protein food source and incident dyslipidemia in Korean adults from the Ansan and Ansung Study and the Health Examinee Study.Frontiers in nutrition · 2023Article
- Influence of Habitual Dairy Food Intake on LDL Cholesterol in a Population-Based Cohort.Nutrients · 2021Article
- Modulation of Lipid Transport and Adipose Tissue Deposition by Small Lipophilic Compounds.Frontiers in cell and developmental biology · 2020Review
- Associations of dietary phytosterols with blood lipid profiles and prevalence of obesity in Chinese adults, a cross-sectional study.Lipids in health and disease · 2018Article
- Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults.Current developments in nutrition · 2017Article
- Short term elevation in dietary protein intake does not worsen insulin resistance or lipids in older adults with metabolic syndrome: a randomized-controlled trial.BMC nutrition · 2017Article
- Feasibility of Conducting a 6-month long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure.Journal of physiotherapy & physical rehabilitation · 2017Article
- Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHyperlipidemia and insulin resistance are risk factors for the development of metabolic syndrome and cardiovascular disease. We have previously observed that supplementation with essential amino acids (EAA) could lower plasma triglycerides, and may improve glucose metabolism.
objectiveWe sought to determine whether EAA's combined with whey protein and phytosterols would facilitate improvements in plasma lipids and insulin sensitivity in adults with mild hypertriglyceridemia.
designWe enrolled nine subjects who were 50 years or older, had a documented plasma TG >150 mg/dl, and had not recently taken statin medications (within 6 weeks). Each subject served as his or her own control. These individuals underwent an oral glucose tolerance test (OGTT) before and after four weeks consumption of the oral nutritional supplement without dietary counseling or recommendations for physical activity.
resultsPlasma total cholesterol and LDL levels decreased in all nine volunteers (
conclusionsThese findings suggest that a dietary supplementation of EAAs and phytosterols may promote favorable reductions of blood lipids as well as insulin resistance in individuals with hypertriglyceridemia. Future larger studies of SNPs and TG response to dietary supplements will be of interest.
Identifiers
26726312PMC4696774W2230847121What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.