ArticleFood hydrocolloids2016
Sodium alginate decreases the permeability of intestinal mucus.
Article in Food hydrocolloids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men.The British journal of nutrition · 2023Trial
- A Dynamic Gastrointestinal Mucus Simulator for Biorelevant Assessment of Nutrient Mucopenetration: Effects of Mucus Purification, Calcium, and Soluble Fibers.Foods (Basel, Switzerland) · 2026Article
- Impact of bile salts, biopolymer coatings, and food matrix on bilosome-mediated delivery of trans-resveratrol.Food chemistry: X · 2026Article
- Alginate/Arabic gum-chitosan-encapsulated Bacillus subtilis enhances probiotic viability and alleviates liver injury and fibrosis in cholestatic rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Prebiotic and Functional Fibers from Micro- and Macroalgae: Gut Microbiota Modulation, Health Benefits, and Food Applications.International journal of molecular sciences · 2025Review
- Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems.Molecular pharmaceutics · 2025Article
- Polymerization of dietary fructans differentially affects interactions among intestinal microbiota of colitis mice.The ISME journal · 2025Article
- Characterization of Acellular Cartilage Matrix-Sodium Alginate Scaffolds in Various Proportions.Tissue engineering. Part C, Methods · 2024Article
- The effect of in vitro digestion on the interaction between polysaccharides derived fromFood science & nutrition · 2024Article
- Innovative approach: utilizing silver nanoparticles sheet for improved rabbit cecal anastomosis healing.Frontiers in veterinary science · 2024Article
- Computer modeling of digestive processes in the alimentary tract and their physiological regulation mechanisms: closing the gap between digestion models andFrontiers in nutrition · 2024Article
- Native gastrointestinal mucus: Critical features and techniques for studying interactions with drugs, drug carriers, and bacteria.Advanced drug delivery reviews · 2023Review
- Development of resveratrol with thiolated alginate as a supplement to prevent nonalcoholic fatty liver disease (NAFLD).APL bioengineering · 2022Article
- The Edible Brown SeaweedNutrients · 2021Article
- Dietary fibre in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2021Review
- Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders.Polymers · 2020Review
- Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation.Nutrients · 2020Article
- The influence of gut microbiota on the rheological characterization of soy hull polysaccharide and mucin interactions.RSC advances · 2020Article
- Permeability of the small intestinal mucus for physiologically relevant studies: Impact of mucus location and ex vivo treatment.Scientific reports · 2019Article
- Zeaxanthin: Metabolism, Properties, and Antioxidant Protection of Eyes, Heart, Liver, and Skin.Antioxidants (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the small intestine the nature of the environment leads to a highly heterogeneous mucus layer primarily composed of the MUC2 mucin. We set out to investigate whether the soluble dietary fibre sodium alginate could alter the permeability of the mucus layer. The alginate was shown to freely diffuse into the mucus and to have minimal effect on the bulk rheology when added at concentrations below 0.1%. Despite this lack of interaction between the mucin and alginate, the addition of alginate had a marked effect on the diffusion of 500 nm probe particles, which decreased as a function of increasing alginate concentration. Finally, we passed a protein stabilised emulsion through a simulation of oral, gastric and small intestinal digestion. We subsequently showed that the addition of 0.1% alginate to porcine intestinal mucus decreased the diffusion of fluorescently labelled lipid present in the emulsion digesta. This reduction may be sufficient to reduce problems associated with high rates of lipid absorption such as hyperlipidaemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.