ArticleScientific reports2016
Cryotherapy Reduces Inflammatory Response Without Altering Muscle Regeneration Process and Extracellular Matrix Remodeling of Rat Muscle.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Local cooling for relieving pain from perineal trauma sustained during childbirth.The Cochrane database of systematic reviews · 2020Pooled it
- A quasi-experimental study on conservative nursing measures for preventing phlebitis in chemotherapy patients.Scientific reports · 2025Trial
- Trial
- Multiple Cryotherapy Attenuates Oxi-Inflammatory Response Following Skeletal Muscle Injury.International journal of environmental research and public health · 2020Trial
- Multiple Cold-Water Immersions Attenuate Muscle Damage but not Alter Systemic Inflammation and Muscle Function Recovery: A Parallel Randomized Controlled Trial.Scientific reports · 2018Trial
- The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise.The Journal of physiology · 2017Trial
- Advancements in the diagnosis and management of complex trimalleolar ankle fractures: A comprehensive review.World journal of orthopedics · 2026Review
- Effects of carbon dioxide hydrate cryotherapy on knee flexor muscle function recovery trajectory after muscle damage: a randomized controlled trial.Frontiers in physiology · 2026Article
- Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans.The Journal of physiology · 2025Article
- Cryotherapy reduces pain post-hemorrhoidectomy (CYPHER): a randomized, controlled, superiority trial of intra-anal ice after surgery for grade III hemorrhoids.Annals of coloproctology · 2025Article
- Isolated and Combined Effects of Cold, Heat and Hypoxia Therapies on Muscle Recovery Following Exercise-Induced Muscle Damage.Sports medicine (Auckland, N.Z.) · 2025Review
- Effects of thermal interventions on skeletal muscle adaptations and regeneration: perspectives on epigenetics: a narrative review.European journal of applied physiology · 2025Review
- Article
- The Effect of Physical Activity and Repeated Whole-Body Cryotherapy on the Expression of Modulators of the Inflammatory Response in Mononuclear Blood Cells among Young Men.Journal of clinical medicine · 2024Article
- Article
- Immediate Effect of Cryo-Compression Therapy on Biomechanical Properties and Perfusion of Forearm Muscles in Mixed Martial Arts Fighters.Journal of clinical medicine · 2024Article
- Pre-exercise cryotherapy reduces myoglobin and creatine kinase levels after eccentric muscle stress in young women.Frontiers in physiology · 2024Article
- Beyond Tissue replacement: The Emerging role of smart implants in healthcare.Materials today. Bio · 2023Review
- Is it the End of the Ice Age?International journal of sports physical therapy · 2023Article
- Role of macrophages during skeletal muscle regeneration and hypertrophy-Implications for immunomodulatory strategies.Physiological reports · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of cryotherapy is widely used in sports medicine today. Cooling could minimize secondary hypoxic injury through the reduction of cellular metabolism and injury area. Conflicting results have also suggested cryotherapy could delay and impair the regeneration process. There are no definitive findings about the effects of cryotherapy on the process of muscle regeneration. The aim of the present study was to evaluate the effects of a clinical-like cryotherapy on inflammation, regeneration and extracellular matrix (ECM) remodeling on the Tibialis anterior (TA) muscle of rats 3, 7 and 14 days post-injury. It was observed that the intermittent application of cryotherapy (three 30-minute sessions, every 2 h) in the first 48 h post-injury decreased inflammatory processes (mRNA levels of TNF-α, NF-κB, TGF-β and MMP-9 and macrophage percentage). Cryotherapy did not alter regeneration markers such as injury area, desmin and Myod expression. Despite regulating Collagen I and III and their growth factors, cryotherapy did not alter collagen deposition. In summary, clinical-like cryotherapy reduces the inflammatory process through the decrease of macrophage infiltration and the accumulation of the inflammatory key markers without influencing muscle injury area and ECM remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.