ArticleOral surgery, oral medicine, oral pathology and oral radiology2016
A novel multimodal optical imaging system for early detection of oral cancer.
Article in Oral surgery, oral medicine, oral pathology and oral radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- AI illuminates paths in oral cancer: transformative insights, diagnostic precision, and personalized strategies.EXCLI journal · 2024Review
- Intra-Oral Photograph Analysis for Gingivitis Screening in Orthodontic Patients.International journal of environmental research and public health · 2023Article
- Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment.Journal of biomedical optics · 2023Article
- Development of a multimodal mobile colposcope for real-time cervical cancer detection.Biomedical optics express · 2022Article
- In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment.Journal of biomedical optics · 2022Article
- A colorful approach towards developing new nano-based imaging contrast agents for improved cancer detection.Biomaterials science · 2021Article
- Multimodal widefield fluorescence imaging with nonlinear optical microscopy workflow for noninvasive oral epithelial neoplasia detection: a preclinical study.Journal of biomedical optics · 2020Article
- Algorithm to quantify nuclear features and confidence intervals for classification of oral neoplasia from high-resolution optical images.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Feasibility of a Video-Mosaicking Approach to Extend the Field-of-View For Reflectance Confocal Microscopy in the Oral Cavity In Vivo.Lasers in surgery and medicine · 2019Article
- Noninvasive diagnostic adjuncts for the evaluation of potentially premalignant oral epithelial lesions: current limitations and future directions.Oral surgery, oral medicine, oral pathology and oral radiology · 2018Review
- Wide-field imaging combined with confocal microscopy using a miniature f/5 camera integrated within a high NA objective lens.Optics letters · 2017Article
- Development of a multimodal foveated endomicroscope for the detection of oral cancer.Biomedical optics express · 2017Article
- Current Practice and Emerging Molecular Imaging Technologies in Oral Cancer Screening.Molecular imagingArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesSeveral imaging techniques have been advocated as clinical adjuncts to improve identification of suspicious oral lesions. However, these have not yet shown superior sensitivity or specificity over conventional oral examination techniques. We developed a multimodal, multi-scale optical imaging system that combines macroscopic biochemical imaging of fluorescence lifetime imaging with subcellular morphologic imaging of reflectance confocal microscopy for early detection of oral cancer. We tested our system on excised human oral tissues. STUDY
designIn total, 4 tissue specimens were imaged. These specimens were diagnosed as either clinically normal, oral lichen planus, gingival hyperplasia, or superficially invasive squamous cell carcinoma. The optical and fluorescence lifetime properties of each specimen were recorded.
resultsBoth quantitative and qualitative differences among normal, benign, and squamous cell carcinoma lesions can be resolved with fluorescence lifetime imaging reflectance confocal microscopy. The results demonstrate that an integrated approach based on these two methods can potentially enable rapid screening and evaluation of large areas of oral epithelial tissue.
conclusionsEarly results from ongoing studies of imaging human oral cavity illustrate the synergistic combination of the 2 modalities. An adjunct device based on such optical characterization of oral mucosa can potentially be used to detect oral carcinogenesis in early stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.