ArticleInfection control and hospital epidemiology2016
Active Surveillance Cultures and Decolonization to Reduce Staphylococcus aureus Infections in the Neonatal Intensive Care Unit.
Article in Infection control and hospital epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Trial
- Factors associated with persistent bloodstream infection in the Neonatal Intensive Care Unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Molecular Epidemiology Clinical Manifestations, Decolonization Strategies, and Treatment Options of Methicillin-ResistantPathogens (Basel, Switzerland) · 2025Review
- Microbiome dysbiosis: a modifiable state and target to prevent Staphylococcus aureus infections and other diseases in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Review
- Healthcare worker perceptions surroundingInfection control and hospital epidemiology · 2023Article
- Visitor restriction during the COVID-19 pandemic did not impact rates ofJournal of perinatal medicine · 2023Article
- A tale of two intensive care units (ICUs): BaselineInfection control and hospital epidemiology · 2023Article
- Article
- Reducing Staphylococcus aureus infections in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Infection prevention for extremely low birth weight infants in the NICU.Seminars in fetal & neonatal medicine · 2022Review
- Management and Prevention of Staphylococcus aureus Infections in Children.Infectious disease clinics of North America · 2022Review
- The effect of routine surveillance and decolonization on the rate of Staphylococcus aureus infections in a level IV neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Bacterial invasive infections in a neonatal intensive care unit: a 13 years microbiological report from an Italian tertiary care centre.Journal of preventive medicine and hygiene · 2020Article
- Colonization profile and duration by multi-resistant organisms in a prospective cohort of newborns after hospital discharge.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Management of early- and late-onset sepsis: results from a survey in 80 German NICUs.Infection · 2019Article
- The Association Between the Developing Nasal Microbiota of Hospitalized Neonates andOpen forum infectious diseases · 2019Article
- Prevention Strategies for Recurrent Community-Associated Staphylococcus aureus Skin and Soft Tissue Infections.Current infectious disease reports · 2019Review
- Article
- Epidemiology and risk factors for recurrent Staphylococcus aureus colonization following active surveillance and decolonization in the NICU.Infection control and hospital epidemiology · 2018Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStaphylococcus aureus is a common cause of healthcare-associated infections in neonates.
objectiveTo examine the impact of methicillin-susceptible S. aureus (MSSA) decolonization on the incidence of MSSA infection and to measure the prevalence of mupirocin resistance.
methodsWe retrospectively identified neonates admitted to a tertiary care neonatal intensive care unit (NICU) from April 1, 2011, through September 30, 2014. We compared rates of MSSA-positive cultures and infections before and after implementation of an active surveillance culture and decolonization intervention for MSSA-colonized neonates. We used 2 measurements to identify the primary outcome, NICU-attributable MSSA: (1) any culture sent during routine clinical care that grew MSSA and (2) any culture that grew MSSA and met criteria of the National Healthcare Safety Network's healthcare-associated infection surveillance definitions. S. aureus isolates were tested for mupirocin susceptibility. We estimated incidence rate ratios using interrupted time-series models.
resultsBefore and after the intervention, 1,523 neonates (29,220 patient-days) and 1,195 neonates (22,045 patient-days) were admitted to the NICU, respectively. There was an immediate reduction in the mean quarterly incidence rate of NICU-attributable MSSA-positive clinical cultures of 64% (incidence rate ratio, 0.36 [95% CI, 0.19-0.70]) after implementation of the intervention, and MSSA-positive culture rates continued to decrease by 21% per quarter (incidence rate ratio, 0.79 [95% CI, 0.74-0.84]). MSSA infections also decreased by 73% immediately following the intervention implementation (incidence rate ratio, 0.27 [95% CI, 0.10-0.79]). No mupirocin resistance was detected.
conclusionActive surveillance cultures and decolonization may be effective in decreasing S. aureus infections in NICUs.
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