ArticleExperimental animals2016
Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model.
Article in Experimental animals, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironment.Molecular biology reports · 2023Review
- Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest.Journal of the American Heart Association · 2021Article
- Abnormal Tryptophan Metabolism in HIV andFrontiers in microbiology · 2021Review
- The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch.Frontiers in immunology · 2020Article
- Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment.Frontiers in immunology · 2019Review
- Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.International journal of molecular sciences · 2018Article
- Psychosocial Stress and Immunity-What Can We Learn From Pig Studies?Frontiers in behavioral neuroscience · 2018Article
- Tryptophan status in autism spectrum disorder and the influence of supplementation on its level.Metabolic brain disease · 2017Article
- Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor.Toxicology and applied pharmacology · 2017Article
- Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors.OncoTargets and therapy · 2017Review
- Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors.International journal of tryptophan research : IJTR · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased activity of the tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is associated with immunological and neurological disorders, and inhibition of its enzyme activity could be a therapeutic approach for treatment of these disorders. The aim of the present study was to establish a large animal model to study the accumulation of the potential IDO inhibitor 1-methyltryptophan (1-MT) in blood and different organs of domestic pigs (Sus scrofa domestica). Because 1-MT has not been previously evaluated in pigs, the pharmacokinetics of a single subcutaneous 1-MT application was investigated. Based on this kinetic study, a profile for repeated 1-MT applications over a period of five days was simulated and tested. The results show that a single administration of 1-MT increases its concentrations in blood, with the maximum concentration being obtained at 12 h. Repeated daily injections of 1‑MT generated increasing plasma concentrations followed by a steady-state after two days. Twelve hours after the final application, accumulation of 1-MT was observed in the brain and other organs, with a substantial variability among various tissues. The concentrations of 1-MT measured in plasma and tissues were similar to, or even higher, than those of tryptophan. Our data indicate that repeated subcutaneous injections of 1-MT provide a suitable model for accumulation of 1-MT in plasma and tissues of domestic pigs. These findings provide a basis for further research on the immunoregulatory functions of IDO in a large animal model.
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