Evidence map›Paper›PMID 26725537›Full record

ReviewJournal of geriatric oncology2016

Comorbidity in older adults with cancer.

Grant R Williams, Amy Mackenzie, Allison Magnuson, Rebecca Olin, Andrew Chapman, Supriya Mohile, Heather Allore, Mark R Somerfield, Valerie Targia, Martine Extermann and 3 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of geriatric oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07136727 (The Impact of Multimodal Digital Fusion AI-Assisted Decision Support System-Based Comprehensive Management on Clinical Outcomes in County-Level Patients With Comorbid Cancer), which is not on this map. Cited by 148 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07136727 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Impact of Multimodal Digital Fusion AI-Assisted Decision Support System-Based Comprehensive Management on Clinical Outcomes in County-Level Patients With Comorbid Cancer:A Prospective Non-randomized Controlled Interventional Study.

TypeinterventionalSponsorThe First Affiliated Hospital of Xinxiang Medical CollegeRan2025 to 2031Enrolled5,000ConditionsOncological Comorbidities (e. g. Hypertension, Diabetes, Malnutrition)ArmsAI-assisted comprehensive management system
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Guideline
  4. Guideline
  5. Pooled it
  6. Trial
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Grant R WilliamsUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: grant.williams@med.unc.edu.
Amy MackenzieThomas Jefferson University, Philadelphia, PA, USA.
Allison MagnusonUniversity of Rochester, Rochester, NY, USA.
Rebecca OlinUniversity of California San Francisco, San Francisco, CA, USA.
Andrew ChapmanThomas Jefferson University, Philadelphia, PA, USA.
Supriya MohileUniversity of Rochester, Rochester, NY, USA.
Heather AlloreYale University, New Haven, CT, USA.
Mark R SomerfieldAmerican Society of Clinical Oncology, Alexandria, VA, USA.
Valerie TargiaSCOREboard, San Diego, CA, USA.
Martine ExtermannH. Lee Moffitt Cancer Center, Tampa, FL, USA.
Harvey Jay CohenDuke University, Durham, NC, USA.
Arti HurriaCity of Hope, Duarte, CA, USA.
Holly HolmesUniversity of Texas, Houston, TX, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Denise Esserman · 2002 to 2026
$37.9M
UNC Oncology K12K12CA120780 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAM Y. KIM · 2007 to 2026
$9.6M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
Reducing Chemotherapy Toxicity in Older AdultsR01CA177592 · NCI · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2013 to 2018
$3.0M
Geriatric Oncology Research to Improve Clinical CareU13AG038151 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HURRIA, ARTI · 2010 to 2014
$228k
Geriatric Assessment - Driven Interventions for Older Cancer PatientsR03AG042342 · NIA · UNIVERSITY OF ROCHESTER · PI MOHILE, SUPRIYA G. · 2012 to 2013
$167k
NCATS NIH HHS UL1 TR001863NCI NIH HHS K12 CA120780NCI NIH HHS R01 CA177592NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA189961NIA NIH HHS P30 AG021342NIA NIH HHS R03 AG042342NIA NIH HHS U13 AG038151
6 · The paper itself

Abstract

Comorbidity is an issue of growing importance due to changing demographics and the increasing number of adults over the age of 65 with cancer. The best approach to the clinical management and decision-making in older adults with comorbid conditions remains unclear. In May 2015, the Cancer and Aging Research Group, in collaboration with the National Cancer Institute and the National Institute on Aging, met to discuss the design and implementation of intervention studies in older adults with cancer. A presentation and discussion on comorbidity measurement, interventions, and future research was included. In this article, we discuss the relevance of comorbidities in cancer, examine the commonly used tools to measure comorbidity, and discuss the future direction of comorbidity research. Incorporating standardized comorbidity measurement, relaxing clinical trial eligibility criteria, and utilizing novel trial designs are critical to developing a larger and more generalizable evidence base to guide the management of these patients. Creating or adapting comorbidity management strategies for use in older adults with cancer is necessary to define optimal care for this growing population.

Indexed as

ComorbiditySeverity of Illness IndexAgedAge FactorsClinical Trials as TopicDecision MakingGeriatric AssessmentHumansMedical OncologyNeoplasmsPrevalenceSurvivorshipAgedCancerComorbidityGeriatric oncologyMultimorbidity

Identifiers

PMID26725537
PMCPMC4917479

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.