Evidence map›Paper›PMID 26725241›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2015

Influence of encapsulated heat shock protein HSP70 on the basic functional properties of blood phagocytes.

O Yu Kochetkova, M M Yurinskaya, M B Evgen'ev, O G Zatsepina, L I Shabarchina, A V Suslikov, S A Tikhonenko, M G Vinokurov

Abstract read
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In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

O Yu KochetkovaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia. o.y.kochetkova@gmail.com.
M M YurinskayaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
M B Evgen'evInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
O G ZatsepinaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
L I ShabarchinaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
A V SuslikovHospital of the Pushchino Scientific Center, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
S A TikhonenkoInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
M G VinokurovInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Institute of Cell Biophysics · RUInstitute of Theoretical and Experimental Biophysics · RUEngelhardt Institute of Molecular Biology · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.

Indexed as

Drug Delivery SystemsApoptosisCell LineDrug CompoundingHSP70 Heat-Shock ProteinsHumansImmunity, InnateMonocytesNeutrophilsPhagocytesReactive Oxygen SpeciesTumor Necrosis Factor-alphaHSP70 Heat-Shock ProteinsReactive Oxygen SpeciesTumor Necrosis Factor-alpha

Identifiers

PMID26725241
OpenAlexW2337851493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.