Evidence map›Paper›PMID 26725100›Full record

ArticleJournal of neuro-oncology2016

The cost-effectiveness of surgical resection and cesium-131 intraoperative brachytherapy versus surgical resection and stereotactic radiosurgery in the treatment of metastatic brain tumors.

A Gabriella Wernicke, Menachem Z Yondorf, Bhupesh Parashar, Dattatreyudu Nori, K S Clifford Chao, John A Boockvar, Susan Pannullo, Philip Stieg, Theodore H Schwartz

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Brachytherapy for central nervous system tumors.Journal of neuro-oncology · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Biodegradable seeds of holmium don't change neurological function after implant in brain of rats.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

A Gabriella WernickeDepartment of Radiation Oncology, Stich Radiation Oncology, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY, 10065, USA. gaw9008@med.cornell.edu.
Menachem Z YondorfDepartment of Radiation Oncology, Stich Radiation Oncology, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY, 10065, USA.
Bhupesh ParasharDepartment of Radiation Oncology, Stich Radiation Oncology, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY, 10065, USA.
Dattatreyudu NoriDepartment of Radiation Oncology, Stich Radiation Oncology, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY, 10065, USA.
K S Clifford ChaoDepartment of Radiation Oncology, Stich Radiation Oncology, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY, 10065, USA.
John A BoockvarDepartment of Neurological Surgery, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA.
Susan PannulloDepartment of Neurological Surgery, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA.
Philip StiegDepartment of Neurological Surgery, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA.
Theodore H SchwartzDepartment of Neurological Surgery, Weill Cornell Medical College of Cornell University, New York Presbyterian Hospital, New York, NY, USA.
Neurological Surgery · USNewYork–Presbyterian Hospital · USPresbyterian Hospital · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
NCATS NIH HHS UL1-TR000457
6 · The paper itself

Abstract

This study aims to evaluate the cost-effectiveness of surgical resection (S) and Cesium-131 (Cs-131) [S + Cs-131] intraoperative brachytherapy versus S and stereotactic radiosurgery (SRS) [S + SRS] for the treatment of brain metastases. Treatment records as well as hospital and outpatient charts of 49 patients with brain metastases between 2008 and 2012 who underwent S + Cs-131 (n = 24) and S + SRS (n = 25) were retrospectively reviewed. Hospital charges were compared for the single treatment in question. Means and curves of survival time were defined by the Kaplan-Meier estimator, with the cost analysis focusing on the time period of the relevant treatment. Quality adjusted life years (QALY) and Incremental cost-effectiveness ratios (ICER) were calculated for each treatment option as a measure of cost-effectiveness. The direct hospital costs of treatments per patient were: S + Cs131 = $19,271 and S + SRS = $44,219. The median survival times of S + Cs-131 and S + SRS were 15.5 and 11.3 months, and the 12 month survival rates were 61 % and 49 % (P = 0.137). The QALY for S + SRS when compared to S + Cs-131 yielded a p < 0.0001, making it significantly more cost-effective. The ICER also revealed that when compared to S + Cs-131, S + SRS was significantly inferior (p < 0.0001). S + Cs-131 is more cost-effective compared with S + SRS based on hospital charges as well as QALYs and ICER. Cost effectiveness, in addition to efficacy and risk, should factor into the comparison between these two treatment modalities for patients with surgically resectable brain metastases.

Indexed as

Cost-Benefit AnalysisAdultAgedAged, 80 and overBrachytherapyBrain NeoplasmsCesium RadioisotopesCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingPrognosisQuality-Adjusted Life YearsCesium RadioisotopesBrain metastasesCesium-131 brachytherapyCost-effectiveness analysisEconomic evaluationIncremental cost-effectiveness ratio (ICER)Quality adjusted life year (QALY)Stereotactic radiosurgery (SRS)

Identifiers

PMID26725100
OpenAlexW2224831837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.