ArticleJournal of neurology2016
Association of seizure duration and outcome in refractory status epilepticus.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between duration of status epilepticus and clinical outcomes in adults: a systematic review.Journal of neurology · 2026Pooled it
- Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial.Epilepsia · 2021Trial
- Article
- Mortality in older adults with epilepsy: An understudied entity.Epilepsia open · 2025Review
- Use of ketamine in Super Refractory Status Epilepticus: a systematic review.Neurological research and practice · 2024Review
- Relationship of Neonatal Seizure Burden Before Treatment and Response to Initial Antiseizure Medication.The Journal of pediatrics · 2024Article
- Semaphorin 4D induced inhibitory synaptogenesis decreases epileptiform activity and alters progression to Status Epilepticus in mice.Epilepsy research · 2023Article
- Current summary of the evidence in drone-based emergency medical services care.Resuscitation plus · 2023Review
- Clinico-biological markers for the prognosis of status epilepticus in adults.Journal of neurology · 2022Article
- Does diabetes mellitus affect the safety profile of valproic acid for the treatment of status epilepticus? A retrospective cohort study.Neurological research and practice · 2022Article
- Isoflurane in (Super-) Refractory Status Epilepticus: A Multicenter Evaluation.Neurocritical care · 2021Article
- [Pharmacotherapy and intensive care aspects of status epilepticus: update 2020/2021].Der Anaesthesist · 2021Review
- Determinants of nutritional status and outcome in adults with RCSE: a retrospective cohort study.BMC neurology · 2021Article
- Quantitative burst suppression on serial intermittent EEG in refractory status epilepticus.Clinical neurophysiology practice · 2021Article
- Treatment of established status epilepticus in the elderly - a study protocol for a prospective multicenter double-blind comparative effectiveness trial (ToSEE).BMC neurology · 2020Article
- Markers in Status Epilepticus Prognosis.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2020Review
- Status epilepticus alert reduces time to administration of second-line antiseizure medications.Neurology. Clinical practice · 2018Article
- Long-term outcomes of status epilepticus: A critical assessment.Epilepsia · 2018Article
- Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.JAMA neurology · 2018Observational
- Updates in Refractory Status Epilepticus.Critical care research and practice · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to identify factors influencing long-term outcome and to evaluate the prognostic power of the Status Epilepticus Severity Score (STESS) in refractory status epilepticus (RSE). We retrospectively extracted data on baseline characteristics, RSE details, and hospital course including complications from all patients treated for RSE in our institution between January 2001 and January 2013. Functional outcome was assessed using the modified Rankin Scale (mRS) and was defined as good when either RSE did not lead to functional decline or when the resulting mRS score was 2 or below. Seventy-one episodes in 65 patients were analyzed. The median follow-up time was 12 weeks (IQR 6-35), two patients were lost to follow-up. Poor functional long-term outcome was observed in 42/69 (60.9%) episodes. In-hospital mortality occurred in 13/71 (18.3%) episodes. Multivariable analysis revealed that STESS ≥ 3, longer RSE duration, and sepsis were independently related to poor functional long-term outcome. Receiver operating characteristics (ROC) curve analyses confirmed the cut-off dichotomization into STESS ≥ 3 and STESS < 3 for optimal discrimination between good and poor outcome (AUC = 0.671, p = 0.002, YI = 0.368, NPV = 0.607, PPV = 0.756) and revealed an RSE duration of 10 days as a significant cut-off point associated with outcome (AUC = 0.712, p = 0.012, YI = 0.310; NPV = 0.545, PPV = 0.750). In conclusion, STESS and RSE duration represent relevant scores and parameters impacting long-term outcome after RSE. A shorter RSE duration is associated with better outcome and, therefore, rapid and adequate treatment for seizure termination should be enforced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.