Evidence map›Paper›PMID 26725085›Full record

ReviewJournal of neurology2016

Multiple sclerosis in men: management considerations.

Riley Bove, Allison McHenry, Kerstin Hellwig, Maria Houtchens, Neda Razaz, Penelope Smyth, Helen Tremlett, A D Sadovnick, D Rintell

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. The influence of menopause on multiple sclerosis.European journal of neurology · 2025
    Article
  5. Article
  6. Observational
  7. Article
  8. Sex differences in predictors of illness intrusiveness in persons with multiple sclerosis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Riley BoveDepartment of Neurology, Sandler Neurosciences Center, University of California, 675 Nelson Rising Lane, San Francisco, CA, 94158, USA. Riley.Bove@ucsf.edu.
Allison McHenryDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Kerstin HellwigSt. Joseph Hospital Neurology Clinic, Ruhr University, Bochum, Germany.
Maria HoutchensDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Neda RazazSchool of Population and Public Health and Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
Penelope SmythDepartment of Neurology, University of Alberta, Edmonton, AB, Canada.
Helen TremlettDivision of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
A D SadovnickDivision of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
D RintellDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Brigham and Women's Hospital · USUniversity of British Columbia · CASt. Josef-Hospital · DEUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a lifelong disease typically affecting individuals in young to middle adulthood. There are recognized sex differences in MS onset and clinical course. MS affects approximately three times more women than men, thus resulting in less attention to the male experience (i.e. diagnosis, management, societal dimensions). Here, we review current scientific evidence on sex differences in MS risk and course, highlight potential sources of bias, and suggest avenues of further inquiry. We then describe what is known about male experiences with MS diagnosis, treatment, and symptom management (particularly mood and sexual function). Finally, we consider ways in which healthcare providers might engage male patients in the broader aspects of living with MS (e.g. familial and societal relationships) to influence their long-term quality of life (QOL). When possible, we draw from published sources to underscore our collective clinical and scientific experiences.

Indexed as

Disease ManagementSex CharacteristicsFemaleHumansMaleMultiple SclerosisDepressionGenderQuality of lifeSex differenceSexual functionSuicide

Identifiers

PMID26725085
OpenAlexW2227849555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.