Evidence map›Paper›PMID 26725065›Full record

ArticleDigestive diseases and sciences2016

Nucleotide-Binding Oligomerization Domain-Containing Protein 2 Variants in Patients with Spontaneous Bacterial Peritonitis.

Murat M M Harputluoglu, Ramazan Dertli, Baris Otlu, Ulvi Demirel, Ozkan Yener, Yilmaz Bilgic, Mehmet Ali Erdogan, Yahya Atayan, Yasir Furkan Cagin

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Article in Digestive diseases and sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021
    Article
  2. Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
  3. Gut-liver axis signaling in portal hypertension.World journal of gastroenterology · 2019
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Murat M M HarputluogluDepartment of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey. mharputluoglu@hotmail.com.ORCID 0000-0002-9415-147X
Ramazan DertliDepartment of Internal Medicine, Medical Faculty, Inonu University, Malatya, Turkey.
Baris OtluDepartment of Microbiology, Medical Faculty, Inonu University, Malatya, Turkey.
Ulvi DemirelDepartment of Gastroenterology, Medical Faculty, Firat University, Elazig, Turkey.
Ozkan YenerDepartment of Microbiology, Medical Faculty, Inonu University, Malatya, Turkey.
Yilmaz BilgicDepartment of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey.
Mehmet Ali ErdoganDepartment of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey.
Yahya AtayanDepartment of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey.
Yasir Furkan CaginDepartment of Gastroenterology, Medical Faculty, Inonu University, Malatya, Turkey.
Inonu University · TRFırat University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe occurrence of spontaneous bacterial peritonitis (SBP) is significantly increased in carriers of nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants, suggesting that local immune alterations might be implicated in bacterial translocation (BT).

aimsWe aimed to assess the role of the NOD2 gene in conferring susceptibility to SBP. We also sought to determine whether levels of serum interleukin-6 (IL-6), lipopolysaccharide-binding protein, and soluble TNF-α receptor, along with the presence of bacterial DNA (bactDNA) in ascitic fluid, are appropriate markers for BT in patients with liver cirrhosis and SBP.

methodsA cohort of 171 patients was divided into two groups: patients with SBP (n = 82) and those without SBP (n = 89). The presence of the most common NOD2 variants (p.R702W, p.G908R, and c.3020insC) was determined in these patients.

resultsWe detected the p.G908R variant in four patients (4.9 %) of the SBP group. No significant difference was observed between the SBP and non-SBP groups for NOD2 risk variants. The frequency of bactDNA in ascitic fluid was higher for patients with NOD2 variants than for patients without variants (p = 0.021). Serum IL-6 levels in the SBP group were higher than those in the non-SBP group.

conclusionsThe frequent detection of bactDNA in ascites of patients with the p.G908R variant suggests there is a strong association between NOD2 risk variants and BT in SBP patients. In addition, increased serum IL-6 levels and bactDNA in ascitic fluid could be considered surrogate markers for BT in patients with cirrhosis.

Indexed as

Genetic Predisposition to DiseaseGenetic VariationAdultAgedBacterial InfectionsBacterial TranslocationFemaleGene Expression RegulationHumansMaleMiddle AgedNod2 Signaling Adaptor ProteinPeritonitisNOD2 protein, humanNod2 Signaling Adaptor ProteinBacterial translocationCirrhosisNOD2Spontaneous bacterial peritonitis

Identifiers

PMID26725065
OpenAlexW2208678932

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.