Evidence map›Paper›PMID 26724968›Full record

ArticleMedical engineering & physics2016

High intensity focused ultrasound as a tool for tissue engineering: Application to cartilage.

Adam B Nover, Gary Y Hou, Yang Han, Shutao Wang, Grace D O'Connell, Gerard A Ateshian, Elisa E Konofagou, Clark T Hung

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical engineering & physics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adam B NoverDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA. Electronic address: abn2106@columbia.edu.
Gary Y HouDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA. Electronic address: yh2367@columbia.edu.
Yang HanDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA. Electronic address: yh2583@columbia.edu.
Shutao WangDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA. Electronic address: sw2735@columbia.edu.
Grace D O'ConnellDepartment of Mechanical Engineering, University of California, Berkeley, USA. Electronic address: g.oconnell@berkeley.edu.
Gerard A AteshianDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA; Department of Mechanical Engineering, Columbia University, 242 S. W. Mudd, 500 West 120th Street, Mail Code: 4703, New York, NY 10027, USA. Electronic address: ateshian@columbia.edu.
Elisa E KonofagouDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA; Department of Radiology, Columbia University, 630 W. 168th Street, P&S Box 28, New York, NY 10032, USA . Electronic address: ek2191@columbia.edu.
Clark T HungDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace, 1210 Amsterdam Avenue, Mail Code: 8904, New York, NY 10027, USA. Electronic address: cth6@columbia.edu.
Columbia University · USUniversity of California, Berkeley · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
PHYSIOLOGIC LOADING FOR CARTILAGE TISSUE ENGINEERINGR01AR046568 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HUNG, CLARK T. · 2000 to 2012
$4.9M
Optimizing Nutrient Supply in Large Engineered Cartilage Tissue ConstructsR01AR060361 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A., HUNG, CLARK T. · 2010 to 2014
$1.7M
Microbubble Infused Hydrogels for Cartilage Tissue EngineeringR21EB014382 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BORDEN, MARK ANDREW, HUNG, CLARK T. · 2011 to 2012
$606k
NIAMS NIH HHS 1R01AR060361NIAMS NIH HHS 2R01AR46568NIAMS NIH HHS R01 AR046568NIAMS NIH HHS R01 AR060361NIBIB NIH HHS 5P41EB002520NIBIB NIH HHS P41 EB002520NIBIB NIH HHS R21 EB014382NIBIB NIH HHS R21EB014382
6 · The paper itself

Abstract

This article promotes the use of High Intensity Focused Ultrasound (HIFU) as a tool for affecting the local properties of tissue engineered constructs in vitro. HIFU is a low cost, non-invasive technique used for eliciting focal thermal elevations at variable depths within tissues. HIFU can be used to denature proteins within constructs, leading to decreased permeability and potentially increased local stiffness. Adverse cell viability effects remain restricted to the affected area. The methods described in this article are explored through the scope of articular cartilage tissue engineering and the fabrication of osteochondral constructs, but may be applied to the engineering of a variety of different tissues.

Indexed as

BiomimeticsUltrasonic WavesAnimalsCartilage, ArticularCattleCell ProliferationCell SurvivalFeasibility StudiesTemperatureTissue EngineeringTissue ScaffoldsArticular cartilageHigh intensity focused ultrasound (HIFU)Osteochondral graftsTissue engineering

Identifiers

PMID26724968
PMCPMC4876027
OpenAlexW2220763783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.