Evidence map›Paper›PMID 26724861›Full record

ArticleCell metabolism2016

FGF21 Regulates Sweet and Alcohol Preference.

Saswata Talukdar, Bryn M Owen, Parkyong Song, Genaro Hernandez, Yuan Zhang, Yingjiang Zhou, William T Scott, Bhavna Paratala, Tod Turner, Andrew Smith and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 8 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 8 syntheses or guidelines pooled it, 326 citations in OpenAlex.

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  3. Liver Brain Interactions: Focus on FGF21 a Systematic Review.International journal of molecular sciences · 2022
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  8. KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Pooled it
  9. Meal sugar-protein balance determines postprandial FGF21 response in humans.American journal of physiology. Endocrinology and metabolism · 2023
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149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Saswata TalukdarCardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
Bryn M OwenDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Parkyong SongDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Genaro HernandezDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yuan ZhangDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yingjiang ZhouCardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
William T ScottDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Bhavna ParatalaDrug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
Tod TurnerCardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
Andrew SmithDrug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
Barbara BernardoDrug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
Christian P MüllerDepartment of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany; MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
Hao TangDepartment of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
David J MangelsdorfDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: davo.mango@utsouthwestern.edu.
Bryan GoodwinCardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
Steven A KliewerDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: steven.kliewer@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USPfizer (United States) · USKing's College London · GB

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V., MINNA, JOHN D. · 1996 to 2024
$57.4M
Tissue-specific Mechanism of Action of the Metabolic Hormones FGF19 and FGF21R01DK067158 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI KLIEWER, STEVEN A. · 2004 to 2017
$4.1M
Predicting Adjuvant Chemotherapy Response in Lung CancerR01CA152301 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI XIE, YANG · 2010 to 2014
$1.5M
Howard Hughes Medical InstituteNCI NIH HHS 5P50 CA70907-16NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA152301NCI NIH HHS R01CA152301NIDDK NIH HHS R01 DK067158NIDDK NIH HHS R01DK067158Wellcome Trust
6 · The paper itself

Abstract

Fibroblast growth factor 21 (FGF21) is a hormone induced by various metabolic stresses, including ketogenic and high-carbohydrate diets, that regulates energy homeostasis. In humans, SNPs in and around the FGF21 gene have been associated with macronutrient preference, including carbohydrate, fat, and protein intake. Here we show that FGF21 administration markedly reduces sweet and alcohol preference in mice and sweet preference in cynomolgus monkeys. In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens. Since analogs of FGF21 are currently undergoing clinical evaluation for the treatment of obesity and type 2 diabetes, our findings raise the possibility that FGF21 administration could affect nutrient preference and other reward behaviors in humans.

Indexed as

AlcoholsAnimalsCentral Nervous SystemDopamineFibroblast Growth FactorsFood PreferencesHaplorhiniHumansMaleMice, Inbred C57BLSaccharinSignal TransductionTasteAlcoholsDopaminefibroblast growth factor 21Fibroblast Growth FactorsSaccharin

Identifiers

PMID26724861
PMCPMC4749404
OpenAlexW2198244887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.