Evidence map›Paper›PMID 26724815›Full record

ArticleJournal of biomolecular NMR2016

Probabilistic validation of protein NMR chemical shift assignments.

Hesam Dashti, Marco Tonelli, Woonghee Lee, William M Westler, Gabriel Cornilescu, Eldon L Ulrich, John L Markley

Abstract read
In one paragraph

Article in Journal of biomolecular NMR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. BioMagResBank (BMRB) as a Resource for Structural Biology.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Integrative NMR for biomolecular research.Journal of biomolecular NMR · 2016
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hesam DashtiGraduate Program in Biophysics, Biochemistry Department, University of Wisconsin-Madison, Madison, WI, USA.
Marco TonelliBiochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
Woonghee LeeBiochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
William M WestlerBiochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
Gabriel CornilescuBiochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA.
Eldon L UlrichBioMagResBank, Biochemistry Department, University of Wisconsin-Madison, Madison, WI, USA.
John L MarkleyBiochemistry Department, National Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI, USA. markley@nmrfam.wisc.edu.

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BUTCHER, SAMUEL E · 2012 to 2019
$9.4M
NIGMS NIH HHS P41 GM103399NIGMS NIH HHS P41GM103399
6 · The paper itself

Abstract

Data validation plays an important role in ensuring the reliability and reproducibility of studies. NMR investigations of the functional properties, dynamics, chemical kinetics, and structures of proteins depend critically on the correctness of chemical shift assignments. We present a novel probabilistic method named ARECA for validating chemical shift assignments that relies on the nuclear Overhauser effect data . ARECA has been evaluated through its application to 26 case studies and has been shown to be complementary to, and usually more reliable than, approaches based on chemical shift databases. ARECA is available online at http://areca.nmrfam.wisc.edu/.

Indexed as

Nuclear Magnetic Resonance, BiomolecularProteinsReproducibility of ResultsProteinsNMR chemical shift assignmentsNOESY experimentProbabilistic methodValidation

Identifiers

PMID26724815
PMCPMC4744101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.