ArticleJournal of affective disorders2016
Altered neural function to happy faces in adolescents with and at risk for depression.
Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Major depressive disorder associated alterations in the effective connectivity of the face processing network: a systematic review.Translational psychiatry · 2024Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Being praised and criticized in adolescents and adults: Age-related changes in neural responses to social evaluations.Developmental cognitive neuroscience · 2026Article
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- Unique versus shared neural correlates of externalizing psychopathology in late childhood.Journal of psychopathology and clinical science · 2024Article
- Neural Correlates of Positive Emotion Processing That Distinguish Healthy Youths at Familial Risk for Bipolar Versus Major Depressive Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Reward Functioning Abnormalities in Adolescents at High Familial Risk for Depressive Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Smaller caudate gray matter volume is associated with greater implicit suicidal ideation in depressed adolescents.Journal of affective disorders · 2021Article
- Differential neural responding to affective stimuli in 6- to 8-year old children at high familial risk for depression: Associations with behavioral reward seeking.Journal of affective disorders · 2019Article
- Hippocampal-subregion functional alterations associated with antidepressant effects and cognitive impairments of electroconvulsive therapy.Psychological medicine · 2019Article
- The neurobiology of self face recognition among depressed adolescents.Journal of affective disorders · 2018Article
- Comparison of Ecological Micro-Expression Recognition in Patients with Depression and Healthy Individuals.Frontiers in behavioral neuroscience · 2017Article
- Reward Processing and Risk for Depression Across Development.Trends in cognitive sciences · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThere is accumulating evidence of alterations in neural circuitry underlying the processing of social-affective information in adolescent Major Depressive Disorder (MDD). However the extent to which such alterations are present in youth at risk for mood disorders remains unclear.
methodWhole-brain blood oxygenation level-dependent task responses and functional connectivity using generalized psychophysiological interaction (gPPI) analyses to mild and intense happy face stimuli was examined in 29 adolescents with MDD (MDD; M age, 16.0, S.D. 1.2 years), 38 healthy adolescents at risk of a mood disorder, by virtue of having a parent diagnosed with either Bipolar Disorder (BD) or MDD (Mood-risk; M age 13.4, S.D. 2.5 years) and 43 healthy control adolescents, having parents with no psychiatric disorder (HC; M age 14.6, S.D. 2.2 years).
resultsRelative to HC adolescents, Mood-risk adolescents showed elevated right dorsolateral prefrontal cortex (DLPFC) activation to 100% intensity happy (vs. neutral) faces and concomitant lowered ventral putamen activity to 50% intensity happy (vs. neutral) faces. gPPI analyses revealed that MDD adolescents showed significantly lower right DLPFC functional connectivity with the ventrolateral PFC (VLPFC) compared to HC to all happy faces. LIMITATIONS: The current study is limited by the smaller number of healthy offspring at risk for MDD compared to BD.
conclusionsBecause Mood-risk adolescents were healthy at the time of the scan, elevated DLPFC and lowered ventral striatal activity in Mood-risk adolescents may be associated with risk or resiliency. In contrast, altered DLPFC-VLPFC functional connectivity in MDD adolescents may be associated with depressed mood state. Such alterations may affect social-affective development and progression to a mood disorder in Mood-risk adolescents. Future longitudinal follow-up studies are needed to directly answer this research question.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.