Evidence map›Paper›PMID 26724517›Full record

Observational studyPreventive medicine2016

Objectively-measured sedentary time and cardiometabolic health in adults with severe obesity.

Wendy C King, Jia-Yuh Chen, Anita P Courcoulas, James E Mitchell, Bruce M Wolfe, Emma J Patterson, William B Inabnet, Gregory F Dakin, David R Flum, Brian Cook and 1 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07229963 (Postprandial Cardiometabolic Effects of Interrupting Sedentary Behavior With Exercise of Varying Intensity in Healthy Overweight Adults), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07229963 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Postprandial Cardiometabolic Effects of Interrupting Sedentary Behavior With Exercise of Varying Intensity in Healthy Overweight Adults

TypeinterventionalSponsorHacettepe UniversityRan2025 to 2026Enrolled16ConditionsCardiovascular Risk Markers, Substrate Oxidation, Postprandial Metabolism, Exercise PhysiologyArmsAerobic Exercise Intervention, Sprint Exercise Intervention, Sedentary Behaviour Intervention
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wendy C KingUniversity of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: kingw@edc.pitt.edu.
Jia-Yuh ChenUniversity of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: jic29@pitt.edu.
Anita P CourcoulasUniversity of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address: courcoulasap@upmc.edu.
James E MitchellNeuropsychiatric Research Institute, Fargo, ND, USA. Electronic address: jmitchell@nrifargo.com.
Bruce M WolfeOregon Health and Science University, Portland, OR, USA. Electronic address: wolfeb@ohsu.edu.
Emma J PattersonLegacy Good Samaritan Weight Management Institute, Portland, OR, USA. Electronic address: epatterson@oregonweightlosssurgery.com.
William B InabnetMount Sinai Hospital, New York, NY, USA. Electronic address: william.inabnet@mountsinai.org.
Gregory F DakinWeill Cornell Medical Center, New York, NY, USA. Electronic address: grd9006@medcornell.edu.
David R FlumUniversity of Washington, Seattle, WA, USA. Electronic address: daveflum@uw.edu.
Brian CookNeuropsychiatric Research Institute, Fargo, ND, USA. Electronic address: briancook@csumb.edu.
Steven H BelleUniversity of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: belle@edc.pitt.edu.

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024996 · NCRR · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2007 to 2011
$49.6M
ZIPRASIDONE IN NORMAL HEPATIC FUNCTION SUBJECTS &IN HEPATIC DYSFUCTIN SUBJECTSM01RR000037 · NCRR · UNIVERSITY OF WASHINGTON · PI PIHOKER, CATHERINE · 1985 to 2007
$33.8M
Continuation of the Longitudinal Assessment of Bariatric Surgery (LABS) - DCCU01DK066557 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BELLE, STEVEN H. · 2003 to 2015
$15.8M
BARIATRIC SURGERY CLINICAL RESEARCH CONSORTIUMU01DK066555 · NIDDK · UNIVERSITY OF CALIFORNIA DAVIS · PI WOLFE, BRUCE M · 2003 to 2013
$6.2M
Effect of Bariatric Surgery on Insulin Resistance &CVDU01DK066585 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COURCOULAS, ANITA P · 2003 to 2013
$5.0M
Bariatric Surgery: Outcomes & Impact on PathophysiologyU01DK066667 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BERK, PAUL DAVID, POMP, ALFONS · 2003 to 2015
$4.7M
Longtitudinal Assessment of Bariatric Surgery (LABS)U01DK066568 · NIDDK · UNIVERSITY OF WASHINGTON · PI FLUM, DAVID R · 2003 to 2013
$4.3M
East Carolina University Bariatric Surgery Clinical CenterU01DK066526 · NIDDK · EAST CAROLINA UNIVERSITY · PI PORIES, WALTER JULIUS · 2003 to 2015
$4.0M
Longitudinal Assessment of Bariatric Surgery (LABS)U01DK066471 · NIDDK · SANFORD RESEARCH NORTH · PI MITCHELL, JAMES EDWARD · 2003 to 2015
$3.7M
NCATS NIH HHS UL1 TR000005NCRR NIH HHS M01 RR000037NCRR NIH HHS M01RR-00037NCRR NIH HHS UL1 RR024153NCRR NIH HHS UL1-RR024153NCRR NIH HHS UL1 RR024996NCRR NIH HHS UL1-RR024996NIDDK NIH HHS U01 DK066471NIDDK NIH HHS U01 DK066526NIDDK NIH HHS U01 DK066555NIDDK NIH HHS U01 DK066557NIDDK NIH HHS U01 DK066568NIDDK NIH HHS U01 DK066585NIDDK NIH HHS U01 DK066667NIDDK NIH HHS U01-DK66471NIDDK NIH HHS U01-DK66526NIDDK NIH HHS U01-DK66555NIDDK NIH HHS U01-DK66568NIDDK NIH HHS U01-DK66585NIDDK NIH HHS U01-DK66667
6 · The paper itself

Abstract

It is unknown whether sedentary behavior is independently associated with the cardiometabolic health of adults with severe obesity. Additionally, there is debate regarding how best to derive meaningful indices of sedentary time (ST) from activity monitor data. A convenience sample of adults with severe obesity (N=927; 79% female, median age 45y, median body mass index (BMI) 46kg/m(2)) completed a research assessment at one of ten US hospitals in 2006-2009 prior to bariatric surgery. Cardiometabolic health was assessed via physical measures, fasting blood samples and medication use. Indices of ST were derived from StepWatch™ activity monitor data with minimum bout durations of 1min, 10min and 30min. Cross-sectional associations were examined. Median (25th, 75th percentile) ST was 9.3h/d (8.1, 10.5) in ≥1min bouts, 6.5h/d (5.2, 8.0) in ≥10min bouts, or 3.2h/d (2.1, 4.5) in ≥30min bouts. Associations with ST were generally strongest with the ≥10min bout duration. Independent of moderate-to-vigorous intensity physical activity, BMI and other potential confounders, 1h/day ST in ≥10min bouts was associated with higher odds of diabetes by 15% (95%CI: 1.05-1.26), metabolic syndrome by 12% (95%CI: 1.01-1.24) and elevated blood pressure by 14% (95%CI: 1.02-1.26), and was associated with 1.4cm (95%CI: 0.9-1.9) larger waist circumference. Findings indicate the importance of considering ST as a distinct health risk among adults with severe obesity, and suggest a 10min minimum duration may be preferable to 1min or 30min for establishing ST from activity monitor data.

Indexed as

Sedentary BehaviorAccelerometryAdultBariatric SurgeryBiomarkersCardiovascular DiseasesCross-Sectional StudiesDiabetes Mellitus, Type 2ExerciseFemaleHumansMaleMetabolic SyndromeMiddle AgedObesity, MorbidRisk FactorsBiomarkersAmbulatory monitoringDiabetes mellitus, type 2Metabolic syndrome XMethodsObesityPhysical activityRisk factorsSedentary bout lengthSedentary lifestyle

Identifiers

PMID26724517
PMCPMC4758881

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.