ArticleCancer epidemiology2016
International Consortium on Mammographic Density: Methodology and population diversity captured across 22 countries.
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Article in Cancer epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16citing papers in PubMed, 1 pooled it
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide.PLoS medicine · 2017Pooled it
- Mammographic Breast Density and Breast Cancer Molecular Subtypes: The Kenyan-African Aspect.BioMed research international · 2018Trial
- Assessment of the Breast Density Prevalence in Swiss Women with a Deep Convolutional Neural Network: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2024Article
- Reproductive factors and mammographic density within the International Consortium of Mammographic Density: A cross-sectional study.Breast cancer research : BCR · 2024Article
- Understanding mammographic breast density profile in China: A Sino-Australian comparative study of breast density using real-world data from cancer screening programs.Asia-Pacific journal of clinical oncology · 2022Article
- The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.Breast cancer research : BCR · 2022Article
- Alcohol and Tobacco Use in Relation to Mammographic Density in 23,456 Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Characteristics of Mammographic Breast Density and Associated Factors for Chinese Women: Results from an Automated Measurement.Journal of oncology · 2019Article
- Childhood body size and midlife mammographic breast density in foreign-born and U.S.-born women in New York City.Annals of epidemiology · 2018Article
- Breast density in multiethnic women presenting for screening mammography.The breast journal · 2018Article
- Cost-Effectiveness of Breast Cancer Screening in Turkey, a Developing Country: Results from Bahçeşehir Mammography Screening Project.European journal of breast health · 2017Article
- Visualization of Breast Microcalcifications on Digital Breast Tomosynthesis and 2-Dimensional Digital Mammography Using Specimens.Breast cancer : basic and clinical research · 2017Article
- Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems.Breast cancer research : BCR · 2016Article
- The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.Oncogene · 2016Article
- The transtheoretical model, health belief model, and breast cancer screening among Iranian women with a family history of breast cancer.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Healthy lifestyle behaviors and the periodicity of mammography screening in Brazilian women.Women's health (London, England)Article
Corrections and comments
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Authors and funding
56 authors.
Valerie A McCormackSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France. Electronic address: mccormackv@iarc.fr.
Anya BurtonSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Isabel dos-Santos-SilvaDept of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
John H HipwellCentre for Medical Image Computing, University College London, UK.
Caroline DickensUniversity of the Witwatersrand, South Africa.
Dorria SalemCairo University, Egypt.
Rasha KamalWoman Imaging Unit, Radiodiagnosis Department, Kasr El Aini, Cairo University Hospitals, Cairo, Egypt.
Mikael HartmanDepartment of Surgery, Yong Loo Lin School of Medicine and Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Charmaine Pei Ling LeeDepartment of Surgery, Yong Loo Lin School of Medicine and Saw Swee Hock School of Public Health, National University of Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
Kee-Seng ChiaNUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
Vahit OzmenIstanbul University, Turkey.
Mustafa Erkin AribalIstanbul University, Turkey.
Anath Arzee FlugelmanNational Cancer Control Center, Israel.
Martín LajousDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA; Center for Research on Population Health, Instituto Nacional de Salud Pública, Mexico, Mexico City, Mexico.
Ruy Lopez-RiduaraCenter for Research on Population Health, Instituto Nacional de Salud Pública, Mexico, Mexico City, Mexico.
Megan RiceChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Isabelle RomieuSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Giske UrsinCancer Registry of Norway, Oslo, Norway; Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Samera QureshiNorwegian Center for Minority Health Research (NAKMI), Oslo, Norway.
Huiyan MaDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, USA.
Eunjung LeeDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Carla H van GilsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
Johanna O P WandersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
Sudhir VinayakAga Khan University Hospital, Nairobi, Kenya.
Rose NdumiaAga Khan University Hospital, Nairobi, Kenya.
Steve AllenDepartment of Imaging, Royal Marsden NHS Foundation Trust, London, UK.
Sarah VinnicombeDivision of Cancer Research, Ninewells Hospital & Medical School, Dundee, UK.
Sue MossWolfson Institute of Preventive Medicine, Queen Mary University of London, UK.
Jong Won LeeAsan Medical Center, Seoul, Republic of Korea.
Jisun KimAsan Medical Center, Seoul, Republic of Korea.
Ana PereiraInstitute of Nutrition and Food Technology, University of Chile, Chile.
Maria Luisa GarmendiaInstitute of Nutrition and Food Technology, University of Chile, Chile.
Reza SirousIsfahan University of Medical Sciences, Isfahan, Iran.
Mehri SirousIsfahan University of Medical Sciences, Isfahan, Iran.
Beata PeplonskaNofer Institute of Occupational Medicine, Łódź, Poland.
Agnieszka BukowskaNofer Institute of Occupational Medicine, Łódź, Poland.
Rulla M TamimiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Kimberly BertrandSlone Epidemiology Center, Boston University, Boston, MA, USA.
Chisato NagataGifu University, Gifu, Japan.
Ava KwongDivision of Breast Surgery, The University of Hong Kong Faculty of Medicine, and Department of Surgery, Hong Kong Sanatorium and Hospital, Hong Kong, People's Republic of China.
Celine VachonDept Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Christopher ScottDept Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Beatriz Perez-GomezCancer Epidemiology Unit, Instituto de Salud Carlos III and CIBERESP, Madrid, Spain.
Marina PollanCancer Epidemiology Unit, Instituto de Salud Carlos III and CIBERESP, Madrid, Spain.
Gertraud MaskarinecUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Graham GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; School of Population and Global Health, The University of Melbourne, Australia.
John HopperSchool of Population and Global Health, The University of Melbourne, Australia.
Jennifer StoneCentre for Genetic Origins of Health and Disease, University of Western Australia, Australia.
Nadia RajaramBreast Cancer Research Group, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Soo-Hwang TeoBreast Cancer Research Group, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia; Cancer Research Malaysia, Subang Jaya, Malaysia.
Shivaani MariapunBreast Cancer Research Group, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Martin J YaffeMedical Biophysics, University of Toronto, Canada.
Joachim SchüzSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Anna M ChiarelliOntario Breast Screening Program, Cancer Care Ontario, Toronto, Canada.
Linda LintonPrincess Margaret Cancer Centre, Toronto, Canada.
Norman F BoydPrincess Margaret Cancer Centre, Toronto, Canada.
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MThe Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MLife Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7MA Mayo Cohort Study of Mammographic Breast DensityR01CA097396 · NCI · MAYO CLINIC ROCHESTER · PI VACHON, CELINE M · 2003 to 2007
$3.1MAutomated Density Measures for Estimating Breast Cancer Risk and Therapy ResponseR01CA177150 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2013 to 2017
$3.0MRisk factors for breast cancer molecular subtypesR01CA140286 · NCI · MAYO CLINIC ROCHESTER · PI KERLIKOWSKE, KARLA M, VACHON, CELINE M · 2010 to 2014
$2.6MWhole Genome Association Study of Mammographic DensityR01CA131332 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2009 to 2012
$1.9MMolecular Predictors of Mammographic DensityR01CA124865 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2008 to 2011
$1.2MNESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITYR01CA085265 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI MASKARINEC, GERTRAUD · 2000 to 2002
$728kCancer Research UK 14565Cancer Research UK G186/11Department of Health 10/57/55Medical Research Council G9000793NCI NIH HHS CA124865NCI NIH HHS CA131332NCI NIH HHS N01 CA015083NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA116201NCI NIH HHS P50CA116201NCI NIH HHS R01 CA085265NCI NIH HHS R01 CA097396NCI NIH HHS R01 CA124865NCI NIH HHS R01 CA131332NCI NIH HHS R01 CA140286NCI NIH HHS R01CA140286NCI NIH HHS R01 CA177150NCI NIH HHS R01CA177150NCI NIH HHS R01CA85265NCI NIH HHS R01CA97396NCI NIH HHS R03 CA167771NCI NIH HHS R03CA167771NCI NIH HHS R37 CA054281NCI NIH HHS R37CA54281NCI NIH HHS UM1 CA176726NCI NIH HHS UM1CA176726NCI NIH HHS UM1 CA186107NCI NIH HHS UM1CA186107World Health Organization 001
Abstract
Mammographic density (MD) is a quantitative trait, measurable in all women, and is among the strongest markers of breast cancer risk. The population-based epidemiology of MD has revealed genetic, lifestyle and societal/environmental determinants, but studies have largely been conducted in women with similar westernized lifestyles living in countries with high breast cancer incidence rates. To benefit from the heterogeneity in risk factors and their combinations worldwide, we created an International Consortium on Mammographic Density (ICMD) to pool individual-level epidemiological and MD data from general population studies worldwide. ICMD aims to characterize determinants of MD more precisely, and to evaluate whether they are consistent across populations worldwide. We included 11755 women, from 27 studies in 22 countries, on whom individual-level risk factor data were pooled and original mammographic images were re-read for ICMD to obtain standardized comparable MD data. In the present article, we present (i) the rationale for this consortium; (ii) characteristics of the studies and women included; and (iii) study methodology to obtain comparable MD data from original re-read films. We also highlight the risk factor heterogeneity captured by such an effort and, thus, the unique insight the pooled study promises to offer through wider exposure ranges, different confounding structures and enhanced power for sub-group analyses.
Indexed as
AdultAgedBreastBreast DensityBreast NeoplasmsFemaleHumansIncidenceInternational AgenciesMammary Glands, HumanMammographyMiddle AgedRisk FactorsBreast cancerInternational ConsortiumMammographic density
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