Evidence map›Paper›PMID 26724389›Full record

ReviewThe American journal of pathology2016

Precision Medicine: Clarity for the Complexity of Dementia.

Brenna Cholerton, Eric B Larson, Joseph F Quinn, Cyrus P Zabetian, Ignacio F Mata, C Dirk Keene, Margaret Flanagan, Paul K Crane, Thomas J Grabowski, Kathleen S Montine and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
  8. [Cognitive function groups in older people and risk factors].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  9. Examining the validity of the Mini-Mental State Examination (MMSE) and its domains using network analysis.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024
    Article
  10. Review
  11. Parkinson's disease therapy: what lies ahead?Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Brenna CholertonDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
Eric B LarsonGroup Health Research Institute, Seattle, Washington.
Joseph F QuinnDepartment of Neurology, Oregon Health and Science University, Portland, Oregon; Portland Veterans Affairs Medical Center, Portland, Oregon.
Cyrus P ZabetianGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Parkinson's Disease Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
Ignacio F MataGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington; Department of Neurology, University of Washington, Seattle, Washington.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, Washington.
Margaret FlanaganDepartment of Pathology, University of Washington, Seattle, Washington.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington.
Thomas J GrabowskiDepartment of Neurology, University of Washington, Seattle, Washington; Department of Radiology, University of Washington, Seattle, Washington.
Kathleen S MontineDepartment of Pathology, University of Washington, Seattle, Washington.
Thomas J MontineDepartment of Pathology, University of Washington, Seattle, Washington. Electronic address: tmontine@uw.edu.

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Outreach, Recruitment and Education CoreP30AG008017 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI DODGE, HIROKO HAYAMA · 1990 to 2019
$27.7M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
Genetic architecture of memory and executive functioning in Alzheimer's diseaseR01AG042437 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K · 2014 to 2017
$2.7M
Using Multiplex Families to map Genes that Modify Susceptibility and Age at OnsetR01NS065070 · NINDS · UNIVERSITY OF WASHINGTON · PI ZABETIAN, CYRUS P · 2009 to 2012
$2.0M
NIA NIH HHS P30 AG008017NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG042437NIA NIH HHS U01 AG006781NINDS NIH HHS P50 NS062684NINDS NIH HHS R01 NS065070
6 · The paper itself

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

Indexed as

Precision MedicineAlzheimer DiseaseCognition DisordersDementiaHumansMutationParkinson Disease

Identifiers

PMID26724389
PMCPMC4816691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.