ReviewAutonomic neuroscience : basic & clinical2016
Mechanisms of orthostatic intolerance during heat stress.
Review in Autonomic neuroscience : basic & clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- Effects of ceiling fan use on cardiovascular autonomic function during simulated indoor overheating in bed-resting older adults.Experimental physiology · 2026Trial
- Postural Instability Is Greater in Men with Type 2 Diabetes after Exertional Heat Stress.Medicine and science in sports and exercise · 2026Trial
- Renal vascular control during normothermia and passive heat stress does not differ between healthy younger men and women.American journal of physiology. Renal physiology · 2024Trial
- Effects of Daylong Exposure to Indoor Overheating on Thermal and Cardiovascular Strain in Older Adults: A Randomized Crossover Trial.Environmental health perspectives · 2024Trial
- Glomerular filtration rate reserve is reduced during mild passive heat stress in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Trial
- Cerebral and peripheral haemodynamics at rest and in response to orthostasis during 3 days of simulated heatwave.Experimental physiology · 2026Article
- The potential efficacy of continuous plantar foot cooling during relatively mild simulated occupational heat stress-a pilot study.European journal of applied physiology · 2026Article
- Cerebrovascular regulation during heat stress.Experimental physiology · 2026Review
- Acute Heat Exposure-Related Illness: A Unified Emergency Medicine Framework for Hot Baths, Hot Springs, and Saunas-A Narrative Review.Journal of clinical medicine · 2026Review
- Orthostatic blood pressure changes among adults in Ekiti state, Nigeria: Impact of socio-demographic, anthropometric, and biophysical factors.Physiological reports · 2026Article
- Changes in physiological parameters and thermal comfort when wearing protective clothing in long-range aeromedical evacuation: a prospective, non-blinded, two-stage crossover self-controlled study.Journal of physiological anthropology · 2025Article
- The combined effects of artificial gravity, temperature, and hypoxia on haemodynamic responses and limb blood flow.European journal of applied physiology · 2025Article
- Directional sensitivity analysis of the cerebral pressure-flow relationship during normothermia and moderate hyperthermia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Regulation of body temperature and blood pressure in women: Mechanisms and implications for heat illness risk.Experimental physiology · 2025Review
- Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study.Physiological reports · 2024Article
- Indoor overheating: A review of vulnerabilities, causes, and strategies to prevent adverse human health outcomes during extreme heat events.Temperature (Austin, Tex.) · 2024Review
- Beating the heat: military training and operations in the era of global warming.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- The effect of age and mitigation strategies during hot water immersion on orthostatic intolerance and thermal stress.Experimental physiology · 2023Article
- Circumferential Strain as a Marker of Vessel Reactivity in Patients with Intradialytic Hypotension.Medicina (Kaunas, Lithuania) · 2023Article
- Cardiovascular responses to orthostasis during a simulated 3-day heatwave.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Heat stress profoundly and unanimously reduces orthostatic tolerance. This review aims to provide an overview of the numerous and multifactorial mechanisms by which this occurs in humans. Potential causal factors include changes in arterial and venous vascular resistance and blood distribution, and the modulation of cardiac output, all of which contribute to the inability to maintain cerebral perfusion during heat and orthostatic stress. A number of countermeasures have been established to improve orthostatic tolerance during heat stress, which alleviate heat stress induced central hypovolemia (e.g., volume expansion) and/or increase peripheral vascular resistance (e.g., skin cooling). Unfortunately, these countermeasures can often be cumbersome to use with populations prone to syncopal episodes. Identifying the mechanisms of inter-individual differences in orthostatic intolerance during heat stress has proven elusive, but could provide greater insights into the development of novel and personalized countermeasures for maintaining or improving orthostatic tolerance during heat stress. This development will be especially impactful in occuational settings and clinical situations that present with orthostatic intolerance and/or central hypovolemia. Such investigations should be considered of vital importance given the impending increased incidence of heat events, and associated cardiovascular challenges that are predicted to occur with the ensuing changes in climate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.