ArticleJournal of natural products2016
Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.
Article in Journal of natural products, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Chemical profile and in vitro antischistosomal activity of Crotalaria madurensis different extracts.Scientific reports · 2026Article
- Antiprotozoal Aminosteroid Alkaloids fromMolecules (Basel, Switzerland) · 2025Article
- The Paradigm Shift of Using Natural Molecules Extracted from Northern Canada to Combat Malaria.Infectious disease reports · 2024Review
- Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications.International journal of molecular sciences · 2022Review
- Multifunctional Therapeutic Potential of Phytocomplexes and Natural Extracts for Antimicrobial Properties.Antibiotics (Basel, Switzerland) · 2021Review
- AntiprotozoalAntibiotics (Basel, Switzerland) · 2021Article
- Temperate Zone Plant Natural Products-A Novel Resource for Activity against Tropical Parasitic Diseases.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Target-Guided Isolation ofMolecules (Basel, Switzerland) · 2020Article
- Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target.Memorias do Instituto Oswaldo Cruz · 2020Article
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- Antimalarial Activity of Plant Metabolites.International journal of molecular sciences · 2018Review
- Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.ACS infectious diseases · 2018Article
- Structure-Activity Relationships of New Natural Product-Based Diaryloxazoles with Selective Activity against Androgen Receptor-Positive Breast Cancer Cells.Journal of medicinal chemistry · 2017Article
- Antimalarial activity of extract and fractions ofAvicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Some of the most valuable antimalarial compounds, including quinine and artemisinin, originated from plants. While these drugs have served important roles over many years for the treatment of malaria, drug resistance has become a widespread problem. Therefore, a critical need exists to identify new compounds that have efficacy against drug-resistant malaria strains. In the current study, extracts prepared from plants readily obtained from local sources were screened for activity against Plasmodium falciparum. Bioassay-guided fractionation was used to identify 18 compounds from five plant species. These compounds included eight lupane triterpenes (1-8), four kaempferol 3-O-rhamnosides (10-13), four kaempferol 3-O-glucosides (14-17), and the known compounds amentoflavone and knipholone. These compounds were tested for their efficacy against multi-drug-resistant malaria parasites and counterscreened against HeLa cells to measure their antimalarial selectivity. Most notably, one of the new lupane triterpenes (3) isolated from the supercritical extract of Buxus sempervirens, the common boxwood, showed activity against both drug-sensitive and -resistant malaria strains at a concentration that was 75-fold more selective for the drug-resistant malaria parasites as compared to HeLa cells. This study demonstrates that new antimalarial compounds with efficacy against drug-resistant strains can be identified from native and introduced plant species in the United States, which traditionally have received scant investigation compared to more heavily explored tropical and semitropical botanical resources from around the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.