ArticleInternational journal of clinical and experimental pathology2015
Tumour necrosis factor alpha, ınterleukin 10 and ınterleukin 6 gene polymorphisms of ıschemic stroke patients ın south Marmara region of Turkey.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Association of Interleukin-6-174G/C Polymorphism With Ischemic Stroke: An Updated Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Association between interleukin-10 -1082A/G polymorphism and risk of ischemic stroke: A meta-analysis.Medicine · 2020Pooled it
- Association of IL-10-1082A/G polymorphism with cardiovascular disease risk: Evidence from a case-control study to an updated meta-analysis.Molecular genetics & genomic medicine · 2019Pooled it
- Interleukins 10 and 1β gene polymorphisms in ischemic stroke risk in the Egyptian population.Scientific reports · 2025Article
- Neurovascular Unit as a Source of Ischemic Stroke Biomarkers-Limitations of Experimental Studies and Perspectives for Clinical Application.Translational stroke research · 2020Review
- Association of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population.Scientific reports · 2018Article
- Identification of Functional Genetic Polymorphisms at IL-10 Promoter Region and their Association with Risk of Ischemic Stroke in Chinese Han Population.The journal of nutrition, health & aging · 2018Article
- Role of Interleukin-10 in Acute Brain Injuries.Frontiers in neurology · 2017Review
- Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis.Bioscience reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is an important cause of adult mortality and morbidity; however its pathogenesis is still unknown. Several studies have examined to determine the role of genetic polymorphism of proinflammatory cytokines in the occurence of stroke. The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNFα)-238 GA, interleukin( IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population.
methodsForty two stroke patients and 48 healhty controls were genotyped using PCR analysis for TNFα-238 G/A, IL-10-1028 GA and IL-6-rs1800795 AG polymorphisms.
resultsThe frequency of the CC and CG, GG genotype of IL-6 gene (rs1800795) were statiscially significiantly higher in IS patients than controls (for C/C genotype, P=0.03, OR=4.3; 95% CI: 1.13 to 16.29 and for C/G genotype, P=0.04, OR=3.6; 95% CI: 1.03 to 12.95, for G/G genotype, P=0.02, OR=0.25; 95% CI: 0.07-0.85 respectively).
conclusionIl-6 CC genotyped was found strongly associated with ischemic stroke than other two polymorpisms TNF-α and IL-10 in our population.
Indexed as
Identifiers
26722564PMC4680509W2222731109What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.