Evidence map›Paper›PMID 26722556›Full record

SynthesisInternational journal of clinical and experimental pathology2015

Association between microRNA polymorphisms and papillary thyroid cancer susceptibility.

Gang Dong, Ruifang Zhang, Jingjing Xu, Yanfei Guo

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC
In one paragraph

Synthesis in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gang DongDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
Ruifang ZhangDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
Jingjing XuDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
Yanfei GuoDepartment of Ultrasound, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPapillary thyroid cancer (PTC) is the most common subtype of thyroid cancer, which accounts for 80-90% of all thyroid cancer cases. Though the pathological mechanism hasn't been fully understood, it is reported that both environmental and genetic factor may contribute to the PTC susceptibility. MicroRNAs (miRNAs) are small non-coding RNA molecules which function as the suppressors to participate in a variety of biological processes. Accumulating evidence suggests that polymorphisms of miRNAs were associated with the tumorigenesis of various cancers, including PTC. In this article, we focus on the association between four common microRNA polymorphisms (miR-146a, miR-608, miR-933, and miR-149) and PTC risk in a Han Chinese population.

methodsIn this case-control study, we recruited 1,398 participants in total, including 369 PTC patients, 278 patients with thyroid benign nodules (BN) and 751 normal controls. The miRNAs polymorphisms were genotyped and analyzed by using MALDI-TOF mass spectrometry. The odd ratios and their 95% confidence interval (95% CI) were calculated to evaluate the association between miRNAs polymorphisms and PTC risk. Furthermore, a meta-analysis based on previous studies was conducted to comprehensively assess the diagnostic performance of miR-146a in the PTC diagnosis.

resultsThe miR-146a polymorphisms were shown to be significantly correlated with elevated risk of PTC under the heterozygous, homozygous, dominant and allelic models by comparing the genotype distribution between PTC cases and healthy controls, as well as between PTC cases and BN cases. However, the result of meta-analysis showed no significant association between miR-146a polymorphisms and PTC risk.

conclusionsOur study indicated that the miR-146a polymorphism was significantly associated with PTC risk. In contrast, meta-analysis revealed no evidence of association between miR-146a variants and PTC risk. Further studies are required to elucidate the role of miR-146a in the etiology of PTC.

Indexed as

AdultAgedAsian PeopleCarcinomaCarcinoma, PapillaryCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMicroRNAsMiddle AgedOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationMicroRNAsMIRN146 microRNA, humanmicroRNAPapillary thyroid cancerpolymorphismthyroid benign nodules

Identifiers

PMID26722556
PMCPMC4680501
OpenAlexW2226799747

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.