ArticleInternational journal of clinical and experimental pathology2015
Quantification of the differential expression levels of microRNA-203 in different degrees of diabetic foot.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in Chronic Diabetic Wound Healing: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- miRNA203 detection via single-strand DNA hybridization and signal amplification by copper-doped cerium oxide nanoparticles.Analytical and bioanalytical chemistry · 2025Article
- Endogenous Biological Drivers in Diabetic Lower Limb Wounds Recurrence: Hypothetical Reflections.International journal of molecular sciences · 2023Review
- A database on differentially expressed microRNAs during rodent bladder healing.Scientific reports · 2021Article
- Cutaneous innervation in impaired diabetic wound healing.Translational research : the journal of laboratory and clinical medicine · 2021Review
- The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds.Molecular therapy. Nucleic acids · 2021Review
- Recent Highlights of Research on miRNAs as Early Potential Biomarkers for Cardiovascular Complications of Type 2 Diabetes Mellitus.International journal of molecular sciences · 2021Review
- Review
- Involvement of miRNA203 in the proliferation of epidermal stem cells during the process of DM chronic wound healing through Wnt signal pathways.Stem cell research & therapy · 2020Article
- miR‑203‑3p participates in the suppression of diabetes‑associated osteogenesis in the jaw bone through targeting Smad1.International journal of molecular medicine · 2018Article
- Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads.Current diabetes reports · 2018Review
- Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells.Organogenesis · 2018Article
- Up-regulation of miR-203 expression induces endothelial inflammatory response: Potential role in preeclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- Biology and Biomarkers for Wound Healing.Plastic and reconstructive surgery · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a common and important complication of diabetes, foot ulcers are characterized by high incidence, poor prognosis and variation in the clinical presentation. The current methods for classification of the diabetic foot are many, but few of them are validated owing to the lack of specific and accurate laboratory index. Thus, the development of new bio-markers to assess and manage diabetic foot is of high importance.
methods46 patients who had undergone wound repairing operation were included in this study and skin tissue samples around the ulcers were collected during the operation. In accordance with The Wound Score of Strauss, all subjects were divided into four groups, such as normal skins group, healthy wounds group, problem wounds group and futile wounds group, and respectively, there are 6, 4, 22, 14 individuals in each group. For each group, we assessed the expression profile of microRNAs (miRNAs) in each skin tissue sample by TaqMan probe-based qRT-PCR assay.
resultSkin-enriched microRNA-203 (miR-203) was readily detected in skin tissue samples, and, in contrast to normal skin tissue, samples from patient with diabetic foot ulcers significantly have a higher expression level in miR-203. Moreover, our study demonstrated the first time that expression profile of miR-203 was positively correlated with the severity of diabetic foot ulcers. Compared with other parameters in wound scoring systems for the assessment of severity of diabetic foot ulcers, the determination for miR-203 was more accurate and validated.
conclusionOur results demonstrated that expression profile of miR-203 in diabetic foot had a positive correlation with the severity of diabetic foot ulcers, which indicated that miR-203 can be served as a new, accurate and validated bio-marker for evaluating the severity of diabetic foot ulcers in clinic. The significant finding of the study: Quantification of miR-203 in different degrees of diabetic foot. This study adds a new bio-marker for evaluation and management of diabetic foot.
Indexed as
Identifiers
26722550PMC4680495W2404399729What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.