ArticleInternational journal of clinical and experimental pathology2015
Correlation between matrix metalloproteinase-9 and endometriosis.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis.Frontiers in endocrinology · 2024Pooled it
- Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets.The Journal of clinical investigation · 2019Trial
- Investigation of endothelin-1 receptor antagonist bosentan in a rat endometriosis model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Determining key residues of engineered scFv antibody variants with improved MMP-9 binding using deep sequencing and machine learning.Computational and structural biotechnology journal · 2024Article
- Possible Correlation between Urocortin 1 (Ucn1) and Immune Parameters in Patients with Endometriosis.International journal of molecular sciences · 2023Article
- Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis.Journal of immunology research · 2023Article
- Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications.Journal of cannabis research · 2022Review
- Circulating proteomic profiles associated with endometriosis in adolescents and young adults.Human reproduction (Oxford, England) · 2022Article
- Metformin Alleviates Endometriosis and Potentiates Endometrial ReceptivityFrontiers in pharmacology · 2022Article
- Unique Sensitivity of Uterine Tissue and the Immune System for Endometriotic Lesion Formation.Frontiers in physiology · 2021Article
- Patterns of Immune Infiltration in Endometriosis and Their Relationship to r-AFS Stages.Frontiers in genetics · 2021Article
- Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2020Review
- Role of B-Cell Translocation Gene 1 in the Pathogenesis of Endometriosis.International journal of molecular sciences · 2019Article
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review).Molecular medicine reports · 2018Review
- Article
- Endometriosis: Epidemiology, Diagnosis and Clinical Management.Current obstetrics and gynecology reports · 2017Article
- Evaluation of two endometriosis models by transplantation of human endometrial tissue fragments and human endometrial mesenchymal cells.International journal of reproductive biomedicine · 2017Article
- Controlling Semi-Invasive Activity of Human Endometrial Stromal Cells by Inhibiting NF-kB Signaling Pathway Using Aloe-emodin and Aspirin.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometrial implantation is the major cause of endometriosis (EMS). Matrix metalloproteinase (MMPs) can degrade multiple extracellular matrix and has been postulated to be related with EMC occurrence. This study thus investigated serum and ascites levels of MMP-9 in EMS patients, in an attempt to discuss the correlation between MMP-9 and EMS. A total of 100 EMS patients, including eutopic endometrium and ectopic endometrium, were recruited in this study along with hysteromyoma patients as the control group. Peripheral blood and ascites samples were collected and tested for MMP-9 levels using gelatin zymogram and enzyme-linked immunosorbent assay (ELISA). In EMS patients, MMP-9 levels in serum and ascites were 6.24 ± 0.53 mM and 38.57 ± 4.93 mM, respectively. Both of them were significantly higher than those in control group (P<0.05). Eutopic endometrium group had higher MMP-9 levels compared to those in ectopic endometrium ones (P<0.05). With advancement of disease stage, EMS patients had progressively elevated MMP-9 levels (P<0.05). Patients at proliferative stage had higher MMP-9 secretion (P<0.05). In summary, site of endometrium, clinical stage and proliferative cycle were independent risk factors for EMS. The elevation of serum and ascites MMP-9 existed in EMS patients, of which those had ectopic endometrium, advanced stage and at proliferative stage had higher MMP-9 expression.
Indexed as
Identifiers
26722547PMC4680492W2410880911What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.