Evidence map›Paper›PMID 26722533›Full record

ArticleInternational journal of clinical and experimental pathology2015

Genetic polymorphisms of pharmacogenomic VIP variants in the lhoba population of southwest China.

Yongjun He, Hua Yang, Tingting Geng, Tian Feng, Dongya Yuan, Longli Kang, Manling Luo, Tianbo Jin

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions.International journal of molecular sciences · 2021
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yongjun HeKey Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China ; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High-Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China.
Hua YangSchool of Life Sciences, Northwest University Xi'an, Shaanxi 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an, Shaanxi 710069, China.
Tingting GengNational Engineering Research Center for Miniaturized Detection Systems Xi'an, Shaanxi 710069, China.
Tian FengNational Engineering Research Center for Miniaturized Detection Systems Xi'an, Shaanxi 710069, China.
Dongya YuanKey Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China ; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High-Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China.
Longli KangKey Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China ; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High-Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China.
Manling LuoDepartment of Blood Transfusion, Second People's Hospital Kunming 650021, Yunnan Province, China.
Tianbo JinKey Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China ; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High-Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, Shaanxi 712082, China ; School of Life Sciences, Northwest University Xi'an, Shaanxi 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an, Shaanxi 710069, China.
Minzu University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is well-established that differences among ethnic groups in drug responses are primarily due to the genetic diversity of pharmacogenes. A number of genes or variants that play a crucial role in drug responses have been designated Very Important Pharmacogenes (VIP) by the PharmGKB database. Clarifying the polymorphic distribution of VIPs in different ethnic groups will aid in personalized medicine for specific populations.

methodsWe sequenced 85 VIP variants in the Lhoba population based on the PharmGKB database. The polymorphic distribution of the 85 VIP variants in 100 Lhoba subjects was determined and compared with that of 11 major HapMap populations, including ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI, and YRI. We used χ(2) tests to identify significantly different loci between these populations. We downloaded SNP allele frequencies from the ALlele FREquency Database to observe the global genetic variation distribution for these specific loci. And then we used Structure software to perform the genetic structure analysis of 12 populations.

resultsBased on comparisons of selected available loci, we found that 23, 28, 16, 10, 20, 16, 24, 19, 22, 21 and 36 of the selected VIP variant genotype frequencies in the Lhoba population differed from those of the ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI, and YRI populations, respectively. In addition, Pairwise FST values and clustering analyses also showed the VIP variants in Lhoba exhibited a close genetic affinity with CHD, CHB and JPT populations.

conclusionOur results complement pharmacogenomic data on the Lhoba ethnic group and may be helpful in the diagnosis of certain diseases in minorities.

Indexed as

Genetic VariationGenotypeHaplotypesAllelesAsian PeopleChinaEthnicityGene FrequencyHumansPharmacogeneticsGenetic polymorphismLhobapharmacogenomicsVIP variants

Identifiers

PMID26722533
PMCPMC4680478
OpenAlexW2222970357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.