ArticleInternational journal of clinical and experimental pathology2015
Clinical and pathological characteristics of extramammary Paget's disease: report of 246 Chinese male patients.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- When the Skin Tells a Bigger Story: Distinguishing Cutaneous Metastases from Primary Adnexal Carcinomas in Dermatopathology.Biology · 2026Review
- Anal adenocarcinoma with perianal Paget's disease: A case report.World journal of gastrointestinal surgery · 2025Article
- Predictors of Dermal Invasion and Sentinel Lymph Node Metastasis in Patients With Extramammary Paget's Disease Without Clinical Lymph Node Enlargement.The Journal of dermatology · 2025Article
- Male external genital skin disorders: a retrospective analysis from a tertiary hospital in China.Frontiers in medicine · 2025Article
- Article
- Independent Risk Factors for Postoperative Recurrence of Patients with Primary Extramammary Paget's Disease: A Retrospective Analysis.Clinical, cosmetic and investigational dermatology · 2024Article
- The clinical and pathological significance of tertiary lymphoid structure in extramammary Paget's disease.Frontiers in immunology · 2024Article
- Triple-negative ectopic breast cancer of the male scrotum: a case report.Frontiers in oncology · 2024Article
- Untargeted metabolomics yields insight into extramammary Paget's disease mechanisms.Frontiers in oncology · 2024Article
- Pathologically Confirmed Subcutaneous Fat and Lymphovascular Invasion of a Hypopigmented Area in Extramammary Paget Disease.Annals of dermatology · 2023Article
- Extramammary Paget Disease: a Therapeutic Challenge, for a Rare Entity.Current oncology reports · 2023Review
- Incidental finding of extramammary Paget's disease during active surveillance for early-stage prostate cancer in a prostate biopsy.IJU case reports · 2023Article
- Current Management and Treatment of Extramammary Paget's Disease.Current treatment options in oncology · 2022Review
- Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.Current oncology (Toronto, Ont.) · 2021Review
- Prevalence of extramammary Paget's disease in urban China: a population-based study.Orphanet journal of rare diseases · 2021Article
- Mucosal Invasion, but Not Incomplete Excision, Has Negative Impact on Long-Term Survival in Patients With Extramammary Paget's Disease.Frontiers in oncology · 2021Article
- Detection ofJournal of oncology · 2021Article
- A primer on extramammary Paget's disease for the urologist.Translational andrology and urology · 2020Review
- Article
- Human epidermal growth factor receptor 2 amplification as a biomarker for treatment in patients with lymph node-metastatic penoscrotal extramammary Paget's disease.Oncology letters · 2019Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extramammary Paget's disease (EMPD) is a rare cutaneous neoplasm. The aim of this study was to elaborate the clinical and pathological features of Chinese EMPD male patients. The study comprised 246 patients with EMPD at our institute from January 1993 to December 2012. Scrotum was the most common initial site. The average age of onset was 63.9 years but the mean delay in diagnosis was 3.6 years. EPMD spread exclusively to the inguinal lymph nodes and the right inguinal lymph nodes are more likely to suffered Paget cells infiltration. Accompanying malignancies were found in 20 patients. Pathological examination revealed 63 patients defined as invasive EMPD. Immunohistochemical detection showed various expression levels of EMA, CEA, CK7, HER2/neu, Ki67, P53, CK20 and S100 in tumor tissues, but negative expression of VIM, LCA and HMB45. HER2/neu protein exhibited a significant association with invasive EMPD. A novel histological type of EMPD with CK7-/S100+ was identified. Elevated serum PSA level was observed in only 16% patients. Invasive EMPD often had advanced age of onset. Metastatic EMPD showed significantly shorter in the delay in diagnosis and the greater length of skin lesion in contrast to others. This study demonstrates the clinical and pathological features of Chinese male EMPD patients, and may provide implications for the management of Chinese EMPD patients.
Indexed as
Identifiers
26722523PMC4680468W2236210010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.