ArticleInternational journal of clinical and experimental pathology2015
Immunohistochemical detection of STAT6, CD34, CD99 and BCL-2 for diagnosing solitary fibrous tumors/hemangiopericytomas.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Solitary Fibrous Tumors of the Breast: Report of Two Cases and Systematic Review.Journal of breast cancer · 2026Article
- The management of solitary fibrous tumor: a single center's experience.Frontiers in surgery · 2026Article
- Complete Resection of a Giant Hypervascular Pelvic Floor Solitary Fibrous Tumor Using Intraoperative Balloon Occlusion and Staged Open Abdomen Management: A Case Report.Surgical case reports · 2026Article
- Article
- Solitary fibrous tumor of the nasal septum: a case report and literature review.Journal of surgical case reports · 2025Article
- A Rare Case of a Huge Solitary Fibrous Tumor in the Kidney.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications.Cancer metastasis reviews · 2024Review
- Epithelioid solitary fibrous tumors from CNS and soft tissues: an unusual morphologic variant.Diagnostic pathology · 2024Article
- Parasagittal meningeal hemangiopericytoma/solitary fibrous tumor: Two case reports and a literature review.Surgical neurology international · 2024Article
- Combination of triple chemotherapy and sequential re-irradiation as salvage for recurrent treatment-refractory hemangiopericytoma of extraspinal dura: a case report.Frontiers in oncology · 2024Article
- Diagnosis and management of a pelvic solitary fibrous tumor in a postmenopausal woman - a case report.Case reports in women's health · 2023Article
- Solitary fibrous tumor of the breast: A case report.International journal of surgery case reports · 2023Article
- Multidisciplinary Treatment of Liver Metastases from Intracranial SFTs/HPCs: A Report of Three Consecutive Cases.Current oncology (Toronto, Ont.) · 2022Article
- Neck glomangiomyoma: A case report and literature review.Molecular and clinical oncology · 2022Article
- ISG15 as a prognostic biomarker in solitary fibrous tumour.Cellular and molecular life sciences : CMLS · 2022Article
- Cerebral Hemangiopericytoma Manifesting as Epilepsia Partialis Continua: A Case Report.JNMA; journal of the Nepal Medical Association · 2022Article
- Aggressive fibromatosis in the submandibular region of a child.Clinical case reports · 2022Article
- Malignant solitary fibrous tumor in the central nervous system treated with surgery, radiotherapy and anlotinib: A case report.World journal of clinical cases · 2022Article
- Malignant renal hemangiopericytoma: a case report.The Pan African medical journal · 2022Article
- Review
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8 authors.
Funding
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Abstract
Solitary fibrous tumors (SFTs)/hemangiopericytomas (HPCs) are uncommon mesenchymal neoplasms of fibroblastic type that can arise anywhere in the body. Recently, NGFI-A binding protein 2 (NAB2)-signal transducer and the activator of transcription 6 (STAT6) fusion gene were discovered as a hallmark of SFTs/HPCs by using whole-exome, and transcriptome sequencing; consequently, the fusion gene can be rapidly detected by STAT6 immunohistochemistry. In this study, 53 formalin-fixed, paraffin-embedded (FFPE) tissues were performed using immunohistochemistry with antibodies against STAT6, CD34, CD99 and Bcl-2. Nuclear STAT6 positive staining was present in 51 cases (51/53, sensitivity 96.2%), which were usually diffuse (4+ in 14 cases; 3+ in 13 cases; 2+ in 9 cases; 1+ in 15 cases) and intense (strong in 17 cases; moderate in 22 cases; and weak in 12 cases) staining. CD34 was positive in 47 cases (47/53, sensitivity 88.7%), CD99 was positive in 50 cases (50/53, sensitivity 94.3%) and Bcl-2 was positive in 51 cases (51/53, sensitivity 96.2%). There is no difference among categories such as age, sex, location, tumor size, or estimated dignity in immunohistochemical staining of STAT6, CD34, CD99 and Bcl-2. The nuclear STAT6 being positive is a helpful and highly sensitive marker in diagnosis of SFTs/HPCs. Considering immunohistochemical STAT6, CD34, CD99 and Bcl-2 findings together can provide more supportive diagnostic information.
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