Evidence map›Paper›PMID 26722511›Full record

ArticleInternational journal of clinical and experimental pathology2015

Associations of interleukin-1 gene cluster polymorphisms with C-reactive protein concentration and lung function decline in smoking-induced chronic obstructive pulmonary disease.

Yu Wang, Karey Shumansky, Don D Sin, S F Paul Man, Loubna Akhabir, John E Connett, Nicholas R Anthonisen, Peter D Paré, Andrew J Sandford, Jian-Qing He

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yu WangDepartment of Respiratory and Critical Medicine, West China Hospital of Sichuan University Chengdu, Sichuan Province, China.
Karey ShumanskyCentre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
Don D SinCentre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
S F Paul ManCentre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
Loubna AkhabirCentre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
John E ConnettDivision of Biostatistics, School of Public Health, University of Minnesota Minneapolis, MN, USA.
Nicholas R AnthonisenFaculty of Medicine, University of Manitoba Winnipeg, MB, Canada.
Peter D ParéCentre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
Andrew J SandfordCentre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
Jian-Qing HeDepartment of Respiratory and Critical Medicine, West China Hospital of Sichuan University Chengdu, Sichuan Province, China ; Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital Vancouver, BC, Canada.
University of Minnesota · US

Funding

REMODELING OF HUMAN AIRWAYS IN DISEASER01HL064068 · NHLBI · UNIVERSITY OF BRITISH COLUMBIA · PI PARE, PETER DAVID · 1999 to 2002
$600k
Canadian Institutes of Health ResearchNHLBI NIH HHS 5R01HL064068-04
6 · The paper itself

Abstract

objectiveWe reported association of haplotypes formed by IL-1b (IL1B)-511C/T (rs16944) and a variable number of tandem repeats (rs2234663) in intron 3 of IL-1 receptor antagonist (IL1RN) with rate of lung function decline in smoking-induced COPD. The aim of current study was to further investigate this association.

methodsWe genotyped an additional 19 polymorphisms in IL1 cluster (including IL1A, IL1B and IL1RN) in non-Hispanic whites who had the fastest (n = 268) and the slowest (n = 292) decline of FEV1% predicted in the same study. We also analyzed the association of all 21 polymorphisms with serum CRP levels.

resultsNone of 21 polymorphisms showed significant association with rate of decline of lung function or CRP levels after adjusting for multiple comparisons. Before adjusting for multiple comparisons, only IL1RN_19327 (rs315949) showed significant association with lung function decline (P = 0.03, additive model). The frequencies of genotypes containing the IL1RN_19327A allele were 71.9% and 62.2%, respectively in the fast and slow decline groups (P = 0.02, odds ratio = 1.6, 95% confidence interval = 1.1-2.3); the IL1B_5200 (rs1143633) and rs2234663 in IL1RN were associated with serum CRP levels (P=0.04 and 0.03, respectively).

conclusionsNo single marker was significantly associated with either rate of lung function decline or serum CRP levels.

Indexed as

AdultAgedC-Reactive ProteinEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseGenotypeHumansInterleukin-1MaleMiddle AgedMultigene FamilyPolymorphism, Single NucleotidePulmonary Disease, Chronic ObstructiveRespiratory Function TestsSmokingC-Reactive ProteinInterleukin-1Chronic obstructive pulmonary disease (COPD)C-reactive proteinforced expiratory volume in one second (FEV1)genetic polymorphismIL1 gene clusterlung function decline

Identifiers

PMID26722511
PMCPMC4680456
OpenAlexW2417908180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.