ArticleInternational journal of clinical and experimental pathology2015
The role of C/EBP-α expression in human liver and liver fibrosis and its relationship with autophagy.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
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- Machine learning and experimental validation identified autophagy signature in hepatic fibrosis.Frontiers in immunology · 2024Article
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- Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Article
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- Tentatively Identified (UPLC/T-TOF-MS/MS) Compounds in the Extract ofMolecules (Basel, Switzerland) · 2022Article
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- Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats.Experimental and therapeutic medicine · 2019Article
- [Role of PPAR-γ-regulated autophagy in genistein-induced inhibition of hepatic stellate cell activation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Article
- Blocking follistatin-like 1 attenuates liver fibrosis in mice by regulating transforming growth factor-beta signaling.International journal of clinical and experimental pathology · 2018Article
- Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency.Gene expression · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of CCAAT enhancer binding protein-α (C/EBP-α) in normal human liver and liver fibrosis and its probable association with autophagy.
methodsDouble label immunohistochemistry was used to detect the location of C/EBP-α in hepatocytes and hepatic stellate cells (HSCs). The expression of C/EBP-α, Atg5, and Atg6 was also evaluated by immunohistochemistry in paraffin sections of human liver. HSC-T6 cells were treated with rapamycin and 3-methyladenine (3MA) to induce or inhibit autophagy, and the expression of C/EBP-α protein was detected by Western blotting.
resultsDouble label immunohistochemistry showed that C/EBP-α was predominantly located in hepatocytes and that its expression was significantly decreased in fibrosis compared with normal liver. Atg5 expression was increased in fibrosis but was located primarily in liver septa and peri-vascular areas, which was consistent with the distribution of HSCs. In contrast, Atg6 was not expressed in normal or fibrotic liver. Treatment of HSC-T6 cells in culture with rapamycin or 3MA decreased or increased C/EBP-α expression, respectively, as shown by Western blotting.
conclusionC/EBP-α was primarily expressed in hepatocytes in normal liver, but its expression decreased significantly in liver fibrosis. Autophagy might play a role in liver fibrosis through its association with C/EBP-α, but this hypothesis warrants further investigation.
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Identifiers
26722507PMC4680452W2417480590What OpenQuestion holds
Registered trials
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