Evidence map›Paper›PMID 26722487›Full record

ArticleInternational journal of clinical and experimental pathology2015

Long non-coding RNA UCA1 may be a novel diagnostic and predictive biomarker in plasma for early gastric cancer.

Jianfei Gao, Rongmei Cao, Hailian Mu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 8 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 8 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  19. Long Non-Coding RNA FGD5-AS1 Induced byFrontiers in cellular and infection microbiology · 2021
    Article
  20. Long Noncoding RNAJournal of oncology · 2021
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jianfei GaoDepartment of Intensive Unit, Linyi People Hospital Linyi, China.
Rongmei CaoDepartment of Gastroenterology, Linyi People Hospital Linyi, China.
Hailian MuDepartment of Gastroenterology, Linyi People Hospital Linyi, China.
Linyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is one of the most common malignancies and ranks the second leading cause of cancer death worldwide. The role of long non-coding RNAs (lncRNAs) in the gastric cancer pathogenesis is largely unknown. The present study is aimed to identify aberrantly expressed lncRNAs involved in the progression of GC. 33 lncRNAs showed significantly differential expression levels between gastric tumor samples and matched normal tissues from 5 pairs of samples using microarray assay. LncRNAs were classified into different subgroups. The expression levels of 4 lncRNAs: HIF1A-AS1, PVT1, CBR3-AS1 and UCA1 both in tumor and plasma were further confirmed in 20 gastric patients by real-time PCR assay. Then, the correlations between the tissue and plasma of these 4 lncRNA levels were assessed. Our data show that there was a significantly positive correlation of UCA1 expression levels between tumor tissues and plasma (r = 0.931). Furthermore, the specificity and sensitivity of PVT-1 and UCA1 were evaluated by receiver operating characteristic (ROC) curve. The results demonstrated that plasma UCA1 provided the higher diagnostic performance for detection of GC (AUC = 0.928; P < 0.001) than PVT-1 (AUC = 0.731; P < 0.01). Taken together, our study suggested that plasma UCA1 levels could be a promising candidate of noninvasive biomarker for GC early diagnosis.

Indexed as

AdultAgedArea Under CurveBiomarkers, TumorEarly Detection of CancerFemaleHumansMaleMiddle AgedOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionRNA, Long NoncodingROC CurveSensitivity and SpecificityStomach NeoplasmsTranscriptomeBiomarkers, TumorRNA, Long NoncodingUCA1 RNA, humanbiomarkerGastric cancerlncRNAUCA1

Identifiers

PMID26722487
PMCPMC4680432
OpenAlexW2410866022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.