ArticleInternational journal of clinical and experimental pathology2015
Morphological study and comprehensive cellular constituents of milky spots in the human omentum.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Overall Survival Advantage of Omentum Preservation Over Omentectomy for Advanced Gastric Cancer: A Systematic Review and Meta-Analysis.World journal of surgery · 2022Pooled it
- Morphological features of serosa-associated lymphoid clusters of the rat parietal pleura: Exploring a relatively unexplored system.Journal of anatomy · 2025Article
- Characteristics and clinical significance of immune cells in omental milky spots of patients with gastric cancer.Frontiers in immunology · 2025Article
- Identification of sex- and inflammation-associated heterogeneity in the mouse omentum.Frontiers in immunology · 2025Article
- Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression.Aging and disease · 2024Review
- Occult Omental Metastasis in Gastric Adenocarcinoma: An Analysis of Incidence, Predictors, and Outcomes.South Asian journal of cancer · 2022Article
- Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis.Clinical & experimental metastasis · 2022Article
- The Immune Microenvironment in Gastric Cancer: Prognostic Prediction.Frontiers in oncology · 2022Review
- Morphological hallmarks facilitating distinction of omental milky spots and lymph nodes: an exploratory study on their discriminative capacity.Histology and histopathology · 2020Article
- Superb microvascular imaging compared with contrast-enhanced ultrasound to assess microvessels in thyroid nodules.Journal of medical ultrasonics (2001) · 2020Article
- The Greater Omentum-A Vibrant and Enigmatic Immunologic Organ Involved in Injury and Infection Resolution.Shock (Augusta, Ga.) · 2020Review
- Sympathetic nerve tissue in milky spots of the human greater omentum.Journal of anatomy · 2020Article
- Evaluating the prognostic significance of tumor-infiltrating lymphocytes in solid tumor: practice of a standardized method from the International Immuno-Oncology Biomarkers Working Group.Cancer management and research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze morphological features of omental milky spots (MS).
methodHematoxylin-eosin staining and immunohistochemistry technique were used to study the omental MS of gastric cancer (GC) patients and rectal cancer (RC) patients. We focused on morphological features of MS and conducted quantitative analysis on the cells number and cellular constituents. Differences in MS parameters between GC and RC were also analyzed.
resultsVarious shapes of MS were mainly round, oval, irregular form in the adipose and perivascular annular. The median MS perimeter was 2752 (range 817~7753) computer-based pixels. The median value of immune cells in one MS was 141 (43~650), comprising T lymphocytes (46.1%), B lymphocytes (28.4%), macrophages (12.4%) and other immune cells (13.1%). Relatively high density of vessels in MS could be calculated by micro-vessel density (MVD) as 4 (0~13). The median value of mesothelial cells loosely arranged in the surface layer was 5 (0~51). There were no significant differences in MS perimeter, MVD, the number of mesothelial cells, total immune cells, T lymphocytes and macrophages between GC and RC (P>0.05), while the number of MS B lymphocytes in RC was significantly higher than that in GC (P<0.001).
conclusionMS are primary immune tissues in the omentum and structural bases for development and progression of peritoneal dissemination of GC and RC. Analyzing the morphology and cellular constituents could help understanding the mechanism of peritoneal metastasis.
Indexed as
Identifiers
26722479PMC4680424W2415245441What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.