ArticleInternational journal of clinical and experimental pathology2015
Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- [Effect of inorganic pyrophosphatase PPA1 on proliferation and apoptosis of abnormal naive cells in acute B-lymphocytic leukemia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Article
- Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations.Life (Basel, Switzerland) · 2025Article
- PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors.Frontiers in oncology · 2022Review
- DNAzyme-Amplified Label-Free Biosensor for the Simple and Sensitive Detection of Pyrophosphatase.Biosensors · 2021Article
- PPA1 Promotes Breast Cancer Proliferation and Metastasis Through PI3K/AKT/GSK3β Signaling Pathway.Frontiers in cell and developmental biology · 2021Article
- Synthesis of Inorganic Pyrophosphatase-Nanodiamond Conjugates Resistant to Calcium and Fluoride.ACS omega · 2020Article
- Serum and tissue proteomic signatures of patients with hepatocellular carcinoma using 2‑D gel electrophoresis.Molecular medicine reports · 2019Article
- Clinical significance and functional validation of inorganic pyrophosphatase in diffuse large B cell lymphoma in humans.Cytotechnology · 2018Article
- PPA1 regulates tumor malignant potential and clinical outcome of colon adenocarcinoma through JNK pathways.Oncotarget · 2017Article
- Clinical significance and functional validation of PPA1 in various tumors.Cancer medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inorganic pyrophosphatase (PPA1) is an enzyme which has been found to be upregulated in various tumors, yet its profile in gastrointestinal cancers has not systemically investigated. In present study, gastrointestinal tissue microarrays were used to evaluate PPA1 expression and the association of PPA1 expression with clinical outcomes was determined for patients with gastric cancer by immunohistochemistry. Overexpression of PPA1 was observed in cancers of the esophagus, stomach, and pancreaticobiliary system. PPA1 was overexpressed in 143 cases (51.3%) of the 279 primary gastric tumors and was associated with larger size (> 3 cm), nodal metastasis and advanced clinical staging (P < 0.05). Moreover, survival analysis demonstrated that PPA1 expression was significantly correlated reduced overall of patients with gastric cancer. Therefore, PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer.
Indexed as
Identifiers
26722435PMC4680380W2470356665What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.