ArticleInternational journal of clinical and experimental pathology2015
A novel long noncoding RNA IRAIN regulates cell proliferation in non small cell lung cancer.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- LncRNA IRAIN inhibits mantle cell lymphoma progression by inducing cell cycle arrest and apoptosis: an in vitro study.Scientific reports · 2026Article
- Long non-coding RNA DLGAP1-AS1 modulates the development of non-small-cell lung cancer via the microRNA-193a-5p/DTL axis.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- Review
- Aberrant allelic-switch of antisense lncRNA IRAIN may be an early diagnostic marker in laryngeal cancer.Oncology letters · 2020Article
- Long non‑coding RNA CCAT1 enhances human non‑small cell lung cancer growth through downregulation of microRNA‑218.Oncology reports · 2020Article
- Long Non-coding RNAFrontiers in oncology · 2020Article
- Long noncoding RNA IRAIN acts as tumor suppressor via miR-125b in multiple myeloma.Oncology letters · 2019Article
- Expression and Effects of Long Non-Coding RNA, LINC01124, in Non-Small Cell Lung Cancer.OncoTargets and therapy · 2019Article
- Targeting the IGF1R Pathway in Breast Cancer Using Antisense lncRNA-Mediated Promoter cis Competition.Molecular therapy. Nucleic acids · 2018Article
- Circulating long noncoding RNA act as potential novel biomarkers for diagnosis and prognosis of non-small cell lung cancer.Molecular oncology · 2018Article
- Long non-coding RNAs function as novel predictors and targets of non-small cell lung cancer: a systematic review and meta-analysis.Oncotarget · 2018Article
- The involvement of lncRNAs in the development and progression of pancreatic cancer.Cancer biology & therapy · 2017Review
- Identification of long noncoding RNAs as potential novel diagnosis and prognosis biomarkers in colorectal cancer.Journal of cancer research and clinical oncology · 2016Article
- Long non-coding RNA IRAIN suppresses apoptosis and promotes proliferation by binding to LSD1 and EZH2 in pancreatic cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lack protein coding potential. LncRNA IRAIN has been verified that it is related to acute myeloid leukemia (AML) and breast cancer. However, there was no study to clarify whether it is involved in non-small cell lung cancer (NSCLC). Here, we demonstrated IRAIN as a tumor promoter in NSCLC. Its expression level was remarkably upregulated in NSCLC tissues and connected with tumor size and smoking status. Knockdown of IRAIN suppressed NSCLC cells proliferation in vitro. These data identify IRAIN as a novel promoting gene, which plays a vital role in tumorigenesis of NSCLC.
Indexed as
Identifiers
26722412PMC4680357What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.