ArticleJournal of Cancer2016
Radiotherapy, Bisphosphonates and Surgical Stabilization of Complete or Impending Pathologic Fractures in Patients with Metastatic Bone Disease.
Article in Journal of Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Questionable indication for postoperative radiotherapy after surgery for metastases of the major long bones: A single-centre cohort study of 552 fractures/526 patients.Journal of bone oncology · 2026Article
- Mitigating dosimetric perturbations from large metal implants utilizing spot-scanning proton arc therapy.Medical dosimetry : official journal of the American Association of Medical Dosimetrists · 2026Article
- Use of the IlluminOss Implant for Treating a Pathologic Humeral Fracture in a Patient with Renal Cell Carcinoma Metastasis: A Case Report.Journal of orthopaedic case reports · 2025Article
- State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines.Cancer metastasis reviews · 2025Review
- Skeletal-Related Events After Surgery With or Without Radiotherapy for Bone Metastases to Weight-Bearing Bones.Cureus · 2022Article
- Management of Long Bones Metastatic Disease: Concepts That We All Know but Not Always Remember.Orthopedic research and reviews · 2022Review
- The Surgical Management of Proximal Femoral Metastases: A Narrative Review.Current oncology (Toronto, Ont.) · 2021Review
- Practice patterns for postoperative radiation therapy in patients with metastases to the long bones: a survey of the Japanese Radiation Oncology Study Group.Journal of radiation research · 2021Article
- The advantages of carbon fiber based orthopedic devices in patients who have to undergo radiotherapy.Acta bio-medica : Atenei Parmensis · 2020Article
- Functional recovery after surgical stabilization and postoperative radiotherapy due to metastases of long bones.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019Article
- Iodine-125 seed implantation combined with arterial chemoembolization therapy for pain palliation in metastatic bone cancer: a retrospective study.Cancer biology & therapy · 2019Article
- Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone.Cancer management and research · 2018Article
- The role of postoperative radiation and coordination of care in patients with metastatic bone disease of the appendicular skeleton.Orthopedic reviews · 2017Article
- Bone Pain and Muscle Weakness in Cancer Patients.Current osteoporosis reports · 2017Review
- Skeletal complications in cancer patients with bone metastases.International journal of urology : official journal of the Japanese Urological Association · 2016Review
- Skeletal Related Events are Rare After Radiation Treatment for Metastatic Disease of the Femur.The Iowa orthopaedic journalArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report the treatment outcomes of patients with metastatic bone disease with complete or impending pathologic fractures, who were treated with postoperative radiotherapy (RT), bisphosphonates or both after orthopedic stabilization. MATERIAL AND
methodsWe retrospectively evaluated the results of RT, bisphosphonates or both after orthopedic stabilization for complete or impending pathologic fractures in 72 patients with skeletal metastases. After surgery, 32 patients (44%) were treated with RT alone (group 1), 31 patients (43%) were treated with RT and bisphosphonates (group 2) and 9 (13%) patients were treated with bisphosphonates (group 3), respectively. Patients were treated with a median dose of 30Gy (30-40 Gy/2-3Gy per fraction).The local tumor progression, pain progression and need for re-operation or re-radiotherapy were assessed from patients' medical records. Median follow-up time was 9 months.
resultsMedian overall survival time was 14 months (95% CI: 12-17). Secondary surgical intervention at the same location was necessary in 1 patient of group 1 (2%), 2 patients of group 2(5%) and 2 patients of group 3 (15%), respectively (p=0.097). Local tumor progress was observed in 3 patients of group 1 (9%), 2 patients of group 2 (7%) and 4 patients in group 3 (44%), respectively (p=0.021). Local pain progress was observed in 19%, 16% and 67% of the same groups (p=0.011).
conclusionOur data confirm the efficacy and necessity of postoperative RT after orthopedic stabilization for metastatic bone disease to control the local disease. Bisphosphonates do not obviate the need for RT in the management of bone metastases after surgical stabilization. The combined treatment might lead to a better local tumor and pain control.
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