Evidence map›Paper›PMID 26722228›Full record

ArticleOncology letters2015

MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells.

Xiao-Yun Li, Jing-Yun Wen, Chang-Chang Jia, Tian-Tian Wang, Xing Li, Min Dong, Q U Lin, Zhan-Hong Chen, Xiao-Kun Ma, L I Wei and 9 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Xiao-Yun LiDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Jing-Yun WenDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Chang-Chang JiaGuangdong Provincial Key Laboratory of Liver Disease Research, Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Tian-Tian WangDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Xing LiDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Min DongDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Q U LinDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Zhan-Hong ChenDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Xiao-Kun MaDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
L I WeiDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Ze-Xiao LinDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Dan-Yun RuanDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Jie ChenDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Dong-Hao WuDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Wei LiuGuangdong Provincial Key Laboratory of Liver Disease Research, Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Yan TaiGuangdong Provincial Key Laboratory of Liver Disease Research, Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Zhi-Yong XiongGuangdong Provincial Key Laboratory of Liver Disease Research, Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Xiang-Yuan WuDepartment of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Q I ZhangGuangdong Provincial Key Laboratory of Liver Disease Research, Sun Yat-sen University, Guangzhou, Gunagdong 510630, P.R. China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mature microRNA (miRNA) 34a-5p, which is a well-known tumor suppressor in hepatitis virus-associated hepatocellular carcinoma (HCC), plays an important role in cell processes, such as cell proliferation and apoptosis, and is therefore an optimal biomarker for future clinical use. However, the role of miRNA-34a-5p in chemoresistance has yet to be identified. In the present study, the expression of miRNA-34a-5p was assessed by an

Indexed as

AXLchemoresistancecisplatinhepatocellular carcinomamicroRNA34a-5p

Identifiers

PMID26722228
PMCPMC4665305
OpenAlexW2111455277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.