ArticleInternational journal of biological sciences2016
A Mechanobiology-based Algorithm to Optimize the Microstructure Geometry of Bone Tissue Scaffolds.
Article in International journal of biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Comparative Hydrodynamic Analysis and Optimization of Gyroid and Diamond Scaffolds with Functionally Graded Porosity.Journal of functional biomaterials · 2026Article
- Smart biomaterials for skeletal aging repair and regeneration.Bone research · 2026Review
- Numerical study of the structural design influence on cartilage cell differentiation in mechanically stimulated hydrogel scaffolds using an FSI-based model.Biomechanics and modeling in mechanobiology · 2025Article
- Biomimetic structural design in 3D-printed scaffolds for bone tissue engineering.Materials today. Bio · 2025Review
- 3D-Printed Triply Periodic Minimal Surface Ceramic Scaffold Loaded With Bone Morphogenetic Protein-2 and Zoledronic for Cranium Defect Repairment.Journal of tissue engineering and regenerative medicine · 2025Article
- Bone Ingrowth Simulation Within the Hexanoid, a Novel Scaffold Design.3D printing and additive manufacturing · 2024Article
- Mechanical and Computational Fluid Dynamic Models for Magnesium-Based Implants.Materials (Basel, Switzerland) · 2024Article
- Optimization of Cobalt-Chromium (Co-Cr) Scaffolds for Bone Tissue Engineering in Endocrine, Metabolic and Immune Disorders.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes.Journal of functional biomaterials · 2023Review
- Unveiling the potential of melt electrowriting in regenerative dental medicine.Acta biomaterialia · 2023Review
- Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair.Frontiers in bioengineering and biotechnology · 2023Review
- Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds.Materials (Basel, Switzerland) · 2022Article
- Hybrid Ti6Al4V/Silk Fibroin Composite for Load-Bearing Implants: A Hierarchical Multifunctional Cellular Scaffold.Materials (Basel, Switzerland) · 2022Article
- Effect of Intramedullary Nailing Patterns on Interfragmentary Strain in a Mouse Femur Fracture: A Parametric Finite Element Analysis.Journal of biomechanical engineering · 2022Article
- Challenges in computational fluid dynamics applications for bone tissue engineering.Proceedings. Mathematical, physical, and engineering sciences · 2022Review
- A mechanobiological computer optimization framework to design scaffolds to enhance bone regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Initial mechanical conditions within an optimized bone scaffold do not ensure bone regeneration - an in silico analysis.Biomechanics and modeling in mechanobiology · 2021Article
- Application of Computational Method in Designing a Unit Cell of Bone Tissue Engineering Scaffold: A Review.Polymers · 2021Review
- An Algorithm to Optimize the Micro-Geometrical Dimensions of Scaffolds with Spherical Pores.Materials (Basel, Switzerland) · 2020Article
- Mechanobiological Approach to Design and Optimize Bone Tissue Scaffolds 3D Printed with Fused Deposition Modeling: A Feasibility Study.Materials (Basel, Switzerland) · 2020Article
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5 authors.
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Abstract
Complexity of scaffold geometries and biological mechanisms involved in the bone generation process make the design of scaffolds a quite challenging task. The most common approaches utilized in bone tissue engineering require costly protocols and time-consuming experiments. In this study we present an algorithm that, combining parametric finite element models of scaffolds with numerical optimization methods and a computational mechano-regulation model, is able to predict the optimal scaffold microstructure. The scaffold geometrical parameters are perturbed until the best geometry that allows the largest amounts of bone to be generated, is reached. We study the effects of the following factors: (1) the shape of the pores; (2) their spatial distribution; (3) the number of pores per unit area. The optimal dimensions of the pores have been determined for different values of scaffold Young's modulus and compression loading acting on the scaffold upper surface. Pores with rectangular section were predicted to lead to the formation of larger amounts of bone compared to square section pores; similarly, elliptic pores were predicted to allow the generation of greater amounts of bone compared to circular pores. The number of pores per unit area appears to have rather negligible effects on the bone regeneration process. Finally, the algorithm predicts that for increasing loads, increasing values of the scaffold Young's modulus are preferable. The results shown in the article represent a proof-of-principle demonstration of the possibility to optimize the scaffold microstructure geometry based on mechanobiological criteria.
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