Evidence map›Paper›PMID 26722126›Full record

Observational studyJournal of the American Heart Association2015

Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris.

Yunpeng Ding, Gard F T Svingen, Eva R Pedersen, Jesse F Gregory, Per M Ueland, Grethe S Tell, Ottar K Nygård

3 registry-linked trialsOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 75 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00354081 phase3completednot on this map

A Randomised Double Blind Study of the Effects of Homocysteine Lowering Therapy on Mortality and Cardiac Events in Patients Undergoing Coronary Angiography

TypeinterventionalSponsorHaukeland University HospitalRan1999 to 2008Enrolled3,096ConditionsCoronary Artery Disease, Myocardial Infarction, Cerebrovascular StrokeArmsfolic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine), folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine), placebo
NCT03180775 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity

TypeinterventionalSponsorRambam Health Care CampusRan2017 to 2018Enrolled110ConditionsAtherosclerosis, Diet Modification, Serum, DiseaseArmsCellulose (control), Glycine, Alanine, Leucine, Isoleucine
NCT03850314 phase2 / phase3unknown statusnot on this mapstarted 2019, after this paper: background citation

The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.

TypeinterventionalSponsorProf. Tony hayek MDRan2019 to 2020Enrolled50ConditionsMetabolic Syndrome, Dyslipidemias, Diabetes Mellitus, ObesityArmsGlycine
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  4. Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yunpeng DingDepartment of Clinical Science, University of Bergen, Norway (Y.D., G.T.S., E.R.P., P.M.U., O.K.N.).
Gard F T SvingenDepartment of Clinical Science, University of Bergen, Norway (Y.D., G.T.S., E.R.P., P.M.U., O.K.N.).
Eva R PedersenDepartment of Clinical Science, University of Bergen, Norway (Y.D., G.T.S., E.R.P., P.M.U., O.K.N.).
Jesse F GregoryFood Science and Human Nutrition Department, University of Florida, Gainesville, FL (J.F.G.).
Per M UelandDepartment of Clinical Science, University of Bergen, Norway (Y.D., G.T.S., E.R.P., P.M.U., O.K.N.) Bevital AS, Bergen, Norway (P.M.U.).
Grethe S TellDepartment of Global Public Health and Primary Care, University of Bergen, Norway (G.S.T.) Norwegian Institute of Public Health, Bergen, Norway (G.S.T.).
Ottar K NygårdDepartment of Clinical Science, University of Bergen, Norway (Y.D., G.T.S., E.R.P., P.M.U., O.K.N.) Department of Heart Disease, Haukeland University Hospital, Bergen, Norway (O.K.N.) KG Jebsen Center for Diabetes Research, Haukeland University Hospital, Bergen, Norway (O.K.N.).
University of Bergen · NONorwegian Institute of Public Health · NOUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. Recently, glycine-dependent reactions have also been linked to lipid metabolism and cholesterol transport. However, little evidence is available on the association between glycine and coronary heart disease. Therefore, we assessed the association between plasma glycine and acute myocardial infarction (AMI). METHODS AND

resultsA total of 4109 participants undergoing coronary angiography for suspected stable angina pectoris were studied. Cox regression was used to estimate the association between plasma glycine and AMI, obtained via linkage to the CVDNOR project. During a median follow-up of 7.4 years, 616 patients (15.0%) experienced an AMI. Plasma glycine was higher in women than in men and was associated with a more favorable baseline lipid profile and lower prevalence of obesity, hypertension, and diabetes mellitus (all P<0.001). After multivariate adjustment for traditional coronary heart disease risk factors, plasma glycine was inversely associated with risk of AMI (hazard ratio per SD: 0.89; 95% CI, 0.82-0.98; P=0.017). The inverse association was generally stronger in those with apolipoprotein B, low-density lipoprotein cholesterol, or apolipoprotein A-1 above the median (all Pinteraction≤0.037).

conclusionsPlasma glycine was inversely associated with risk of AMI in patients with suspected stable angina pectoris. The associations were stronger in patients with apolipoprotein B, low-density lipoprotein cholesterol, or apolipoprotein A-1 levels above the median. These results motivate further studies to elucidate the relationship between glycine and lipid metabolism, in particular in relation to cholesterol transport and atherosclerosis. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT00354081.

Indexed as

AgedAngina, StableApolipoprotein A-IApolipoprotein B-100BiomarkersCholesterol, LDLCoronary AngiographyDisease ProgressionFemaleGlycineHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNorwayAPOA1 protein, humanAPOB protein, humanApolipoprotein A-IApolipoprotein B-100BiomarkersCholesterol, LDLGlycineamino acidsapolipoproteinatherosclerosisglycinelipids and lipoprotein metabolismmyocardial infarction

Identifiers

PMID26722126
PMCPMC4859380
OpenAlexW2261754997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.