Evidence map›Paper›PMID 26722110›Full record

ArticleAntimicrobial agents and chemotherapy2016

Clinafloxacin for Treatment of Burkholderia cenocepacia Infection in a Cystic Fibrosis Patient.

Akshu Balwan, David P Nicolau, Minkey Wungwattana, Jonathan B Zuckerman, Valerie Waters

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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  5. New Auranofin Analogs with Antibacterial Properties againstAntibiotics (Basel, Switzerland) · 2021
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  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Akshu BalwanDivision of Pulmonary & Critical Care, Maine Medical Center, Portland, Maine, USA.
David P NicolauCenter for Anti-Infective Research & Development, Hartford Hospital, Hartford, Connecticut, USA.
Minkey WungwattanaDepartment of Pharmacy, Maine Medical Center, Portland, Maine, USA.
Jonathan B ZuckermanDivision of Pulmonary & Critical Care, Maine Medical Center, Portland, Maine, USA jzuckerman@cmamaine.com Valerie.waters@sickkids.ca.
Valerie WatersDivision of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada jzuckerman@cmamaine.com Valerie.waters@sickkids.ca.
Maine Medical Center · USHartford Hospital · USHospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory infection with Burkholderia cenocepacia is associated with accelerated decline in lung function and increased mortality in cystic fibrosis (CF) patients (A. M. Jones, M. E. Dodd, J. R. W. Govan, V. Barcus, C. J. Doherty, J. Morris, and A. K. Webb, Thorax 59:948-951, 2004, http://dx.doi.org/10.1136/thx.2003.017210). B. cenocepacia often possesses innate resistance to multiple antimicrobial classes, making eradication uncommon in established infection (P. B. Davis, Am J Respir Crit Care Med 173:475-482, 2006, http://dx.doi.org/10.1164/rccm.200505-840OE). We report the use of clinafloxacin in a CF patient with advanced B. cenocepacia infection, present pharmacokinetic (PK) data, and discuss the potential therapeutic role of clinafloxacin in patients with this condition.

Indexed as

AdultAnti-Bacterial AgentsBurkholderia cenocepaciaBurkholderia InfectionsCystic FibrosisDiabetes ComplicationsDiabetes MellitusExocrine Pancreatic InsufficiencyFatal OutcomeFluoroquinolonesHumansLungMalePseudomonas aeruginosaPseudomonas InfectionsTreatment FailureAnti-Bacterial AgentsclinafloxacinFluoroquinolones

Identifiers

PMID26722110
PMCPMC4704148
OpenAlexW2208343223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.