ArticleSocial cognitive and affective neuroscience2016
GABA content within the ventromedial prefrontal cortex is related to trait anxiety.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Neuroimaging Insights: Kava's (Nutrients · 2023Trial
- Trait anxiety negatively modulates the coupling of motor event-related desynchronization and event-related synchronization.BMC psychiatry · 2025Article
- Discriminative functional connectivity signature of cocaine use disorder links to rTMS treatment response.Nature. Mental health · 2024Article
- Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons.Molecular psychiatry · 2023Article
- Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex.Nature communications · 2023Article
- A generalizable functional connectivity signature characterizes brain dysfunction and links to rTMS treatment response in cocaine use disorder.medRxiv : the preprint server for health sciences · 2023Article
- The effect of parietal glutamate/GABA balance on test anxiety levels in early childhood in a cross-sectional and longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Functions of the ventromedial prefrontal cortex in emotion regulation under stress.Scientific reports · 2021Article
- Agitation and Dementia: Prevention and Treatment Strategies in Acute and Chronic Conditions.Frontiers in neurology · 2021Review
- High γ-Aminobutyric Acid Content Within the Medial Prefrontal Cortex Is a Functional Signature of Somatic Symptoms Disorder in Patients With Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Differential effects of GABAPsychopharmacology · 2020Article
- Elucidating the putative link between prefrontal neurotransmission, functional connectivity, and affective symptoms in irritable bowel syndrome.Scientific reports · 2019Article
- Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The role of mid-insula in the relationship between cardiac interoceptive attention and anxiety: evidence from an fMRI study.Scientific reports · 2018Article
- Observational
- GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity.Brain structure & function · 2017Article
- Functional and neurochemical interactions within the amygdala-medial prefrontal cortex circuit and their relevance to emotional processing.Brain structure & function · 2017Article
- Gender Differences in Food Choice: Effects of Superior Temporal Sulcus Stimulation.Frontiers in human neuroscience · 2017Article
- GABA Concentrations in the Anterior Cingulate Cortex Are Associated with Fear Network Function and Fear Recovery in Humans.Frontiers in human neuroscience · 2017Article
- GABA levels in the ventromedial prefrontal cortex during the viewing of appetitive and disgusting food images.Neuroscience · 2016Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ventromedial prefrontal cortex (vmPFC) plays a key role in emotion processing and regulation. vmPFC dysfunction may lead to disinhibition of amygdala causing high anxiety levels. γ-Aminobutyric acid (GABA) inter-neurons within vmPFC shape the information flow to amygdala. Thus, we hypothesize that GABA content within vmPFC could be relevant to trait anxiety. Forty-three healthy volunteers aged between 20 and 88 years were assessed for trait anxiety with the Subscale-2 of the State-Trait-Anxiety Inventory (STAI-Y2) and were studied with proton magnetic resonance spectroscopy to investigate GABA and Glx (glutamate+glutamine) contents within vmPFC. Total creatine (tCr) was used as internal reference. Partial correlations assessed the association between metabolite levels and STAI-Y2 scores, removing the effect of possible nuisance factors including age, educational level, volumes of gray matter and white matter within magnetic resonance spectroscopy voxel. We observed a positive relationship between GABA/tCr and STAI-Y2 scores. No significant relationships were found between Glx/tCr and STAI-Y2 and between tCr/water and STAI-Y2. No differences were found between males and females as regards to age, STAI-Y2, GABA/tCr, Glx/tCr, tCr/water, gray matter and white matter volumes. We suggest a close relationship between GABA content within vmPFC and trait anxiety providing new insights in the physiology of emotional brain.
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