Evidence map›Paper›PMID 26722001›Full record

ArticleScience (New York, N.Y.)2016

Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior.

Emily A Ferenczi, Kelly A Zalocusky, Conor Liston, Logan Grosenick, Melissa R Warden, Debha Amatya, Kiefer Katovich, Hershel Mehta, Brian Patenaude, Charu Ramakrishnan and 5 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03737032 (Theta Burst Stimulation in Young Adults With Depression), which is not on this map. Cited by 320 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
320citing papers in PubMed, 10 pooled it
30.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03737032 nacompletednot on this mapstarted 2020, after this paper: background citation

Theta Burst Stimulation in Young Adults With Depression

TypeinterventionalSponsorErika ForbesRan2020 to 2022Enrolled29ConditionsDepressionArmsIntermittent Theta Burst Stimulation, Continuous Theta Burst Stimulation, Sham Theta Burst Stimulation
3 · Its place in the literature

Who cites it

320 citing papers in PubMed, 10 syntheses or guidelines pooled it, 540 citations in OpenAlex.

  1. Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024
    Pooled it
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  5. Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022
    Pooled it
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  7. Meta-analysis of human prediction error for incentives, perception, cognition, and action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Pooled it
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  16. The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
  17. Field potential 1/Journal of neurophysiology · 2019
    Trial
  18. Article
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  20. Article

260 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Emily A Ferenczi *Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Kelly A Zalocusky *Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Conor Liston *Brain Mind Research Institute, Weill Cornell Medical College, New York, NY 10065, USA.
Logan GrosenickDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Melissa R WardenDepartment of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA.
Debha AmatyaDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Kiefer KatovichDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Hershel MehtaDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Brian PatenaudeDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Paul KalanithiDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Amit EtkinDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Brian KnutsonDepartment of Psychology, Stanford University, Stanford, CA 94305, USA.
Gary H GloverDepartment of Radiology, Stanford University, Stanford, CA, 94305, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Stanford University · USCornell University · USHoward Hughes Medical Institute · US

Funding

Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
OPTICAL NEUROMODULATION TECHNOLOGY FOR LONG TIMESCALESR01MH086373 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2010 to 2025
$9.1M
Structural and molecular identification of circuitry underlying joint processing of motivation and aversionR37DA035377 · NIDA · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2013 to 2022
$6.2M
Imaging the Evolving Neural Circuit Dynamics of DepressionDP2MH109982 · NIMH · CORNELL UNIVERSITY · PI WARDEN, MELISSA RHOADS · 2015 to 2015
$2.3M
Chronic Stress Effects on Connectivity in a Limbic CircuitR00MH097822 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LISTON, CONOR M · 2014 to 2016
$747k
Dopamine D2 Receptor Signaling Impacts on Risk-Based Decision MakingF31MH105151 · NIMH · STANFORD UNIVERSITY · PI ZALOCUSKY, KELLY ANNE · 2014 to 2015
$57k
NEURAL SIGNALING IN BONE MARROWF30MH010515 · NIMH · UNIVERSITY OF ROCHESTER · PI GIBSON-BERRY, KIMBERLY L · 1993 to 1996
–
Howard Hughes Medical InstituteNIBIB NIH HHS P41 EB015891NIMH NIH HHS 1F31MH105151_01NIMH NIH HHS F31 MH105151NIMH NIH HHS R00 MH097822
6 · The paper itself

Abstract

Motivation for reward drives adaptive behaviors, whereas impairment of reward perception and experience (anhedonia) can contribute to psychiatric diseases, including depression and schizophrenia. We sought to test the hypothesis that the medial prefrontal cortex (mPFC) controls interactions among specific subcortical regions that govern hedonic responses. By using optogenetic functional magnetic resonance imaging to locally manipulate but globally visualize neural activity in rats, we found that dopamine neuron stimulation drives striatal activity, whereas locally increased mPFC excitability reduces this striatal response and inhibits the behavioral drive for dopaminergic stimulation. This chronic mPFC overactivity also stably suppresses natural reward-motivated behaviors and induces specific new brainwide functional interactions, which predict the degree of anhedonia in individuals. These findings describe a mechanism by which mPFC modulates expression of reward-seeking behavior, by regulating the dynamical interactions between specific distant subcortical regions.

Indexed as

MotivationRewardAnhedoniaAnimalsBrain MappingCorpus StriatumDepressive DisorderDopamineDopaminergic NeuronsFemaleMagnetic Resonance ImagingMaleMesencephalonNerve NetOxygenPrefrontal CortexDopamineOxygen

Identifiers

PMID26722001
PMCPMC4772156
OpenAlexW2210805002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.