ArticleTrends in hearing2015
Reducing Current Spread by Use of a Novel Pulse Shape for Electrical Stimulation of the Auditory Nerve.
Article in Trends in hearing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Power-efficient ramped stimulation in a fully implantable cochlear implant.Scientific reports · 2025Article
- Electrical equivalent circuit for analyzing the effect of signal shape on power distribution in cochlear implant electrodes and surrounding tissue.Scientific reports · 2025Article
- What Is the Benefit of Ramped Pulse Shapes for Activating Auditory Cortex Neurons? An Electrophysiological Study in an Animal Model of Cochlear Implant.Brain sciences · 2023Article
- Understanding degraded speech leads to perceptual gating of a brainstem reflex in human listeners.PLoS biology · 2021Article
- In vivo microstimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice.Journal of neuroscience research · 2020Article
- An evaluation of the effect of pulse-shape on grey and white matter stimulation in the rat brain.Scientific reports · 2018Article
- Advancing Binaural Cochlear Implant Technology.Trends in hearing · 2015Review
- Limitations on Temporal Processing by Cochlear Implant Users: A Compilation of Viewpoints.Trends in hearingReview
- Influence of the Electrode-Neuron Interface and Asymmetry of Pulses on the Spread of Excitation in Cochlear Implants: A Computational Study.Trends in hearingReview
- Review
- Article
- The Perception of Ramped Pulse Shapes in Cochlear Implant Users.Trends in hearingArticle
- A Phenomenological Model Reproducing Temporal Response Characteristics of an Electrically Stimulated Auditory Nerve Fiber.Trends in hearingArticle
- Article
- An Adaptive Leaky-Integrate and Firing Probability Model of an Electrically Stimulated Auditory Nerve Fiber.Trends in hearingArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Improving the electrode-neuron interface to reduce current spread between individual electrodes has been identified as one of the main objectives in the search for future improvements in cochlear-implant performance. Here, we address this problem by presenting a novel stimulation strategy that takes account of the biophysical properties of the auditory neurons (spiral ganglion neurons, SGNs) stimulated in electrical hearing. This new strategy employs a ramped pulse shape, where the maximum amplitude is achieved through a linear slope in the injected current. We present the theoretical framework that supports this new strategy and that suggests it will improve the modulation of SGNs' activity by exploiting their sensitivity to the rising slope of current pulses. The theoretical consequence of this sensitivity to the slope is a reduction in the spread of excitation within the cochlea and, consequently, an increase in the neural dynamic range. To explore the impact of the novel stimulation method on neural activity, we performed in vitro recordings of SGNs in culture. We show that the stimulus efficacy required to evoke action potentials in SGNs falls as the stimulus slope decreases. This work lays the foundation for a novel, and more biomimetic, stimulation strategy with considerable potential for implementation in cochlear-implant technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.