Observational studyCirculation. Heart failure2016
Association of Serum Erythropoietin With Cardiovascular Events, Kidney Function Decline, and Mortality: The Health Aging and Body Composition Study.
Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph
Observational study in Circulation. Heart failure, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Patient-Centred Outcomes in Anaemia and Renal Disease: A Systematic Review.Kidney diseases (Basel, Switzerland) · 2020Pooled it
- Multidisciplinary and Personalized Molecular Diagnosis to Solving Sudden Death During Sport.Molecular diagnosis & therapy · 2026Review
- Prognostic value of hemoglobin-to-serum creatinine ratio in patients with coronary artery disease and reduced kidney function following percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2026Article
- Haematometabolism rewiring in atherosclerotic cardiovascular disease.Nature reviews. Cardiology · 2025Review
- Anemia Management in the Cardiorenal Patient: A Nephrological Perspective.Journal of the American Heart Association · 2025Review
- Nontraditional Factors Influencing Cardiovascular Disease Risk: Correlation Among Framingham Risk Score, Body Composition Index, and Sleep-Breathing Monitoring Index.Clinical and translational science · 2025Article
- Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker.Current cardiology reviews · 2025Review
- Association of gene polymorphism in ERG rs2836411 with anemia and susceptibility to aortic dissection.BMC cardiovascular disorders · 2024Article
- Safety Implications of Off-Label Medication Use in Athletes: A Narrative Review.Medicines (Basel, Switzerland) · 2024Review
- The treatment of chronic anemia in heart failure: a global approach.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Identification of independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4: the construction of a nomogram.Frontiers in nutrition · 2024Article
- Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice.Frontiers in physiology · 2024Article
- A Rationally Designed Complex Replenishes the Transferrin Iron Pool Directly and with High Specificity.Journal of the American Chemical Society · 2023Article
- Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Age and genotype dependent erythropoietin protection in COVID-19.World journal of stem cells · 2021Review
- Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.Cancer medicine journal · 2021Article
- Dietary Restriction for Kidney Protection: Decline in Nephroprotective Mechanisms During Aging.Frontiers in physiology · 2021Review
- Low erythropoietin levels predict faster renal function decline in diabetic patients with anemia: a prospective cohort study.Scientific reports · 2019Article
- Genetic compensation byCell cycle (Georgetown, Tex.) · 2019Article
- Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 1 country.
Pranav S GarimellaFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Ronit KatzFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Kushang V PatelFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Stephen B KritchevskyFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Chirag R ParikhFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Joachim H IxFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Linda F FriedFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Anne B NewmanFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Michael G ShlipakFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Tamara B HarrisFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.).
Mark J SarnakFrom the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, MA (P.S.G., M.J.S.); Kidney Research Institute (R.K.) and Department of Anesthesiology and Pain Medicine (K.V.P.), University of Washington, Seattle; Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC (S.B.K.); Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, CT (C.R.P.); Nephrology Section, Veterans Affairs San Diego Healthcare System and Division of Nephrology and Preventive Medicine, University of California, San Diego (J.H.I.); Renal Section, VA Pittsburgh Healthcare System (L.F.F.) and Department of Epidemiology, Graduate School of Public Health (A.B.N.), University of Pittsburgh, PA; Department of Epidemiology, Biostatistics, and Medicine, University of California, San Francisco (M.G.S.); Department of General Internal Medicine, San Francisco VA Medical Center, CA (M.G.S.); and Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MA (T.B.H.). msarnak@tuftsmedicalcenter.org.
Health ABC Study
VA Pittsburgh Healthcare System · USSan Francisco VA Medical Center · USYale University · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USVA San Diego Healthcare System · USWake Forest University · US
Funding
The Aging Kidney: Chronic Injury, Impaired Functions and Clinical OutcomesR01AG027002 · NIA · TUFTS MEDICAL CENTER · PI PARIKH, SAMIR M, SARNAK, MARK J · 2005 to 2022
$7.3MPeripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5MEnd of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7MDYNAMICS OF HEALTH .AGING . AND BODY COMPOSITION /Pittsburgh/-260962101N01AG062101 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 1996 to 2004
$996kDYNAMICS OF HEALTH . AGING . AND BODY COMPOSITION /Memphis/-26062103N01AG062103 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 1996 to 2004
$793kHEALTH ABC--COORDINATING UNIT /California/-260062106N01AG062106 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1996 to 2004
$109kIntramural NIH HHSNIA NIH HHS 5R01AG027002NIA NIH HHS N01-AG-6-2101NIA NIH HHS N01-AG-6-2103NIA NIH HHS N01-AG-6-2106NIA NIH HHS R01 AG027002NIA NIH HHS R01 AG028050NIA NIH HHS R01-AG028050NIMHD NIH HHS MD-07-080NINR NIH HHS R01 NR012459NINR NIH HHS R01-NR012459
Abstract
backgroundStudies suggest that in patients with heart failure (HF), high serum erythropoietin is associated with risk of recurrent HF and mortality. Trials of erythropoietin-stimulating agents in persons with kidney disease have also suggested an increased incidence of adverse clinical events. No large studies of which we are aware have evaluated the association of endogenous erythropoietin levels with clinical outcomes in the community-living older adults. METHODS AND
resultsErythropoietin concentration was measured in 2488 participants aged 70-79 years in the Health, Aging and Body Composition Study. Associations of erythropoietin with incident HF, coronary heart disease, stroke, mortality, and ≥ 30% decline in estimated glomerular filtration rate were examined using Cox proportional hazards and logistic regression over 10.7 years of follow-up. Mean (SD) age was 75 (3) years and median (quartile 1, quartile 3) erythropoietin was 12.3 (9.0, 17.2) mIU/mL. There were 503 incident HF events, and each doubling of serum erythropoietin was associated with a 25% increased risk of incident HF 1.25 (95% confidence interval 1.13, 1.48) after adjusting for demographics, prevalent cardiovascular disease, cardiovascular disease risk factors, kidney function, and serum hemoglobin. There was no interaction of serum erythropoietin with chronic kidney disease or anemia (P > 0.50). There were 330 incident coronary heart disease events, 161 strokes, 1112 deaths, and 698 outcomes of ≥ 30% decline in estimated glomerular filtration rate. Serum erythropoietin was not significantly associated with these outcomes.
conclusionsHigher levels of endogenous erythropoietin are associated with incident HF in older adults. Studies need to elucidate the mechanisms through which endogenous erythropoietin levels associate with specific outcomes.
Indexed as
Body CompositionAgedAge FactorsAgingBiomarkersErythropoietinFemaleGlomerular Filtration RateHeart FailureHumansIncidenceKaplan-Meier EstimateKidneyLogistic ModelsLongitudinal StudiesMaleBiomarkersEPO protein, humanErythropoietincardiovascular outcomes chronic kidney disease death erythropoietin heart failure
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