Evidence map›Paper›PMID 26721704›Full record

ArticleJournal of theoretical biology2016

Treatment-donation-stockpile dynamics in ebola convalescent blood transfusion therapy.

Xi Huo, Xiaodan Sun, Kunquan Lan, Jianhong Wu

Abstract read
In one paragraph

Article in Journal of theoretical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xi HuoDepartment of Mathematics, Ryerson University, Toronto, Ontario, Canada M5B 2K3; Centre for Disease Modelling, York Institute for Health Research, and Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada M3J 1P3.
Xiaodan SunCentre for Disease Modelling, York Institute for Health Research, and Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada M3J 1P3; School of Mathematics and Statistics, Xi׳an Jiaotong University, Xi׳an, Shaanxi, China.
Kunquan LanDepartment of Mathematics, Ryerson University, Toronto, Ontario, Canada M5B 2K3.
Jianhong WuCentre for Disease Modelling, York Institute for Health Research, and Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada M3J 1P3. Electronic address: wujh@mathstat.yorku.ca.

Funding

Canadian Institutes of Health Research 289907
6 · The paper itself

Abstract

The interim guidance issued by the World Health Organization during the West Africa 2014 Ebola outbreak provides guidelines on the use of convalescent blood from Ebola survivors for transfusion therapy. Here we develop a novel mathematical model, based on the interim guidance, to examine the nonlinear transmission-treatment-donation-stockpile dynamics during an Ebola outbreak and with a large scale use of the transfusion therapy in the population. We estimate the reduction of case fatality ratio by introducing convalescent blood transfusion as a therapy, and inform optimal treatment-donation-stockpile strategies to balance the treatment need for case fatality ratio reduction and the strategic need of maintaining a minimal blood bank stockpile for other control priorities.

Indexed as

Blood TransfusionConvalescenceDisease OutbreaksModels, BiologicalAfrica, WesternBlood DonorsFemaleHemorrhagic Fever, EbolaHumansMaleConvalescent blood transfusionEbola treatmentPopulation dynamics

Identifiers

PMID26721704
PMCPMC7094096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.