ArticleJournal of experimental botany2016
The CA domain of the respiratory complex I is required for normal embryogenesis in Arabidopsis thaliana.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- PCIS1 is an essential factor in mitochondrial RNA splicing and complex I biogenesis, with distinct effects in null and downregulated mutants.Plant cell reports · 2026Article
- Article
- C1-FDX is required for the assembly of mitochondrial complex I and subcomplexes of complex V in Arabidopsis.PLoS genetics · 2024Article
- The biogenesis and regulation of the plant oxidative phosphorylation system.Plant physiology · 2023Review
- OsαCA1 Affects Photosynthesis, Yield Potential, and Water Use Efficiency in Rice.International journal of molecular sciences · 2023Article
- Article
- Temporal Control of Seed Development in Dicots: Molecular Bases, Ecological Impact and Possible Evolutionary Ramifications.International journal of molecular sciences · 2021Review
- Molecular cloning and transcriptional regulation of two γ-carbonic anhydrase genes in the green macroalga Ulva prolifera.Genetica · 2021Article
- Mitochondrial Pentatricopeptide Repeat Protein, EMB2794, Plays a Pivotal Role in NADH Dehydrogenase Subunit nad2 mRNA Maturation in Arabidopsis thaliana.Plant & cell physiology · 2020Article
- Different Types Domains are Present in Complex I from Immature Seeds and of CA Adult Plants in Arabidopsis thaliana.Plant & cell physiology · 2019Article
- Translocase of the Outer Mitochondrial Membrane 40 Is Required for Mitochondrial Biogenesis and Embryo Development inFrontiers in plant science · 2019Article
- Respiratory chain Complex I of unparalleled divergence in diplonemids.The Journal of biological chemistry · 2018Article
- Conserved in situ arrangement of complex I and IIIProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression.Journal of proteomics · 2018Article
- Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation ofThe Plant cell · 2017Article
- Article
- Life without complex I: proteome analyses of an Arabidopsis mutant lacking the mitochondrial NADH dehydrogenase complex.Journal of experimental botany · 2016Article
- Respiratory complex I and embryo development.Journal of experimental botany · 2016Article
- EMB2217 Is a Mitochondrial PPR-SMR Protein Required for the Splicing of Multiple Group II Introns During Arabidopsis Development.Physiologia plantarumArticle
- Transcriptomic analysis reveals the participation of NTRC in iron homeostasis in Arabidopsis.Physiologia plantarumArticle
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Abstract
The NADH-ubiquinone oxidoreductase [complex I (CI), EC 1.6.5.3] of the mitochondrial respiratory chain is the principal entry point of electrons, and vital in maintaining metabolism and the redox balance. In a variety of eukaryotic organisms, except animal and fungi (Opisthokonta), it contains an extra domain composed of putative gamma carbonic anhydrases subunits, named the CA domain, which was proposed to be essential for complex I assembly. There are two kinds of carbonic anhydrase subunits: CAs (of which there are three) and carbonic anhydrase-like proteins (CALs) (of which there are two). In plants, the CA domain has been linked to photorespiration. In this work, we report that Arabidopsis mutant plants affected in two specific CA subunits show a lethal phenotype. Double homozygous knockouts ca1ca2 embryos show a significant developmental delay compared to the non-homozygous embryos, which show a wild-type (WT) phenotype in the same silique. Mutant embryos show impaired mitochondrial membrane potential and mitochondrial reactive oxygen species (ROS) accumulation. The characteristic embryo greening does not take place and fewer but larger oil bodies are present. Although seeds look dark brown and wrinkled, they are able to germinate 12 d later than WT seeds. However, they die immediately, most likely due to oxidative stress.Since the CA domain is required for complex I biogenesis, it is predicted that in ca1ca2 mutants no complex I could be formed, triggering the lethal phenotype. The in vivo composition of a functional CA domain is proposed.
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