ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Dysregulation of oxygen hemodynamic responses to synaptic train stimulation in a rat hippocampal model of subarachnoid hemorrhage.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Contrasting Metabolic Insufficiency in Aging and Dementia.Aging and disease · 2021Review
- Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences.Nature communications · 2021Article
- Four-dimensional computed tomography angiography analysis of internal carotid arteries opacification at the skull base to detect delayed cerebral ischemia: a feasibility study.International journal of computer assisted radiology and surgery · 2020Article
- Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair.Progress in neurobiologyReview
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
We investigated microvascular reactivity to synaptic train stimulation after induction of subarachnoid hemorrhage in adult rats, analyzing tissue oxygen levels [pO2] in intact hippocampus. In control rats, hippocampal pO2averaged 11.4 mm Hg whereas hemodynamic responses averaged 13.1 mm Hg (to a 25 s train). After subarachnoid hemorrhage (at 2 days), we recorded a dramatic elevation in baseline pO2in the hippocampus (to 68.4 mm Hg) accompanied by inverted pO2responses to synaptic train stimulation (-9.46 mm Hg). These significant changes in baseline hippocampal pO2and inverted pO2responses after subarachnoid hemorrhage indicate severe alterations of neurovascular coupling and neuronal viability.
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