ArticleNeurobiology of disease2016
Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks.
Article in Neurobiology of disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 82 citations in OpenAlex.
- The basal ganglia and the epilepsies.Epilepsia open · 2026Review
- Nanophotonic neural probes for in vivo photostimulation, electrophysiology, and microfluidic delivery.Microsystems & nanoengineering · 2026Article
- Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats.Epilepsia · 2026Article
- Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A review of cell-type specific circuit mechanisms underlying epilepsy.Acta epileptologica · 2024Review
- Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications.Pflugers Archiv : European journal of physiology · 2023Article
- Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures.Brain : a journal of neurology · 2023Article
- Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice.Behavioral and brain functions : BBF · 2023Article
- Noradrenergic pathway from the locus coeruleus to heart is implicated in modulating SUDEP.iScience · 2023Article
- Towards translational optogenetics.Nature biomedical engineering · 2023Review
- Optogenetic and chemogenetic manipulation of seizure threshold in mice.STAR protocols · 2023Article
- Optogenetic activation of the superior colliculus attenuates spontaneous seizures in the pilocarpine model of temporal lobe epilepsy.Epilepsia · 2023Article
- Cannabidiol attenuates generalized tonic-clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain.Pharmacological reports : PR · 2023Article
- Structural connections of the centromedian nucleus of thalamus and their relevance for neuromodulation in generalized drug-resistant epilepsy: insight from a tractography study.Therapeutic advances in neurological disorders · 2023Article
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures.Progress in neurobiology · 2022Article
- Article
- Disruption of Cerebellar-Cerebral Functional Connectivity in Temporal Lobe Epilepsy and the Connection to Language and Cognitive Functions.Frontiers in neuroscience · 2022Article
- Identifying the neural network for neuromodulation in epilepsy through connectomics and graphs.Brain communications · 2022Article
- Distinct Fastigial Output Channels and Their Impact on Temporal Lobe Seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Because sites of seizure origin may be unknown or multifocal, identifying targets from which activation can suppress seizures originating in diverse networks is essential. We evaluated the ability of optogenetic activation of the deep/intermediate layers of the superior colliculus (DLSC) to fill this role. Optogenetic activation of DLSC suppressed behavioral and electrographic seizures in the pentylenetetrazole (forebrain+brainstem seizures) and Area Tempestas (forebrain/complex partial seizures) models; this effect was specific to activation of DLSC, and not neighboring structures. DLSC activation likewise attenuated seizures evoked by gamma butyrolactone (thalamocortical/absence seizures), or acoustic stimulation of genetically epilepsy prone rates (brainstem seizures). Anticonvulsant effects were seen with stimulation frequencies as low as 5 Hz. Unlike previous applications of optogenetics for the control of seizures, activation of DLSC exerted broad-spectrum anticonvulsant actions, attenuating seizures originating in diverse and distal brain networks. These data indicate that DLSC is a promising target for optogenetic control of epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.