ArticleJournal of biomedical optics2015
Explicit dosimetry for 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a-mediated photodynamic therapy: macroscopic singlet oxygen modeling.
Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study.Journal of biomedical optics · 2022Article
- Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots.Molecules (Basel, Switzerland) · 2020Review
- Reactive oxygen species explicit dosimetry to predict local tumor growth for Photofrin-mediated photodynamic therapy.Biomedical optics express · 2020Article
- Local and Systemic Antitumor Effects of Photo-activatable Paclitaxel Prodrug on Rat Breast Tumor Models.Photochemistry and photobiology · 2020Article
- In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines.Photochemistry and photobiology · 2020Article
- Article
- Reactive oxygen species explicit dosimetry to predict tumor growth for benzoporphyrin derivative-mediated vascular photodynamic therapy.Journal of biomedical optics · 2020Article
- Singlet oxygen model evaluation of interstitial photodynamic therapy with 5-aminolevulinic acid for malignant brain tumor.Journal of biomedical optics · 2019Article
- Reactive oxygen species explicit dosimetry to predict local tumor control for Photofrin-mediated photodynamic therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Reactive oxygen species explicit dosimetry to predict tumor growth for BPD-mediated vascular photodynamic therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- A Comparison of Dose Metrics to Predict Local Tumor Control for Photofrin-mediated Photodynamic Therapy.Photochemistry and photobiology · 2017Article
- On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling.Physics in medicine and biology · 2017Review
- Evaluation of singlet oxygen explicit dosimetry for predicting treatment outcomes of benzoporphyrin derivative monoacid ring A-mediated photodynamic therapy.Journal of biomedical optics · 2017Article
- Article
- Evaluation of the 2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling.Journal of biophotonics · 2016Article
- Explicit macroscopic singlet oxygen modeling for benzoporphyrin derivative monoacid ring A (BPD)-mediated photodynamic therapy.Journal of photochemistry and photobiology. B, Biology · 2016Article
- Macroscopic singlet oxygen modeling for dosimetry of Photofrin-mediated photodynamic therapy: an in-vivo study.Journal of biomedical optics · 2016Article
- Deformable medical image registration of pleural cavity for photodynamic therapy by using finite-element based method.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Dosimetry study of PHOTOFRIN-mediated photodynamic therapy in a mouse tumor model.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Investigating the impact of oxygen concentration and blood flow variation on photodynamic therapy.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Type II photodynamic therapy (PDT) is based on the photochemical reactions mediated through an interaction between a photosensitizer, ground-state oxygen ([(3)O2]), and light excitation at an appropriate wavelength, which results in production of reactive singlet oxygen ([(1)O2]rx). We use an empirical macroscopic model based on four photochemical parameters for the calculation of [(1)O2]rx threshold concentration ([(1)O2]rx,sh) causing tissue necrosis in tumors after PDT. For this reason, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH)-mediated PDT was performed interstitially on mice with radiation-induced fibrosarcoma (RIF) tumors. A linear light source at 665 nm with total energy released per unit length of 12 to 100 J/cm and source power per unit length (LS) of 12 to 150 mW/cm was used to induce different radii of necrosis. Then the amount of [(1)O2]rx calculated by the macroscopic model incorporating explicit PDT dosimetry of light fluence distribution, tissue optical properties, and HPPH concentration was correlated to the necrotic radius to obtain the model parameters and [(1)O2]rx,sh. We provide evidence that [(1)O2]rx is a better dosimetric quantity for predicting the treatment outcome than PDT dose, which is proportional to the time integral of the products of the photosensitizer concentration and light fluence rate.
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