Evidence map›Paper›PMID 26720870›Full record

ArticleJournal of biomedical optics2015

Calibration of diffuse correlation spectroscopy blood flow index with venous-occlusion diffuse optical spectroscopy in skeletal muscle.

Zhe Li, Wesley B Baker, Ashwin B Parthasarathy, Tiffany S Ko, Detian Wang, Steven Schenkel, Turgut Durduran, Gang Li, Arjun G Yodh

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  14. Noninvasive optical monitoring of critical closing pressure and arteriole compliance in human subjects.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
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  17. Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS).IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhe LiUniversity of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United StatesbTianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, ChinacTianjin Univer.
Wesley B BakerUniversity of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States.
Ashwin B ParthasarathyUniversity of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States.
Tiffany S KoUniversity of Pennsylvania, Department of Bioengineering, 210 South 33rd Street, Philadelphia, Pennsylvania 19104, United States.
Detian WangUniversity of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United StateseInstitute of Fluid Physics, Mianyang 621000, China.
Steven SchenkelUniversity of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States.
Turgut DurduranICFO-Institut de Ciéncies Fotóniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona), Spain.
Gang LiTianjin University, School of Precision Instrument and Opto-Electronics Engineering, Tianjin 300072, ChinacTianjin University, State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin 300072, China.
Arjun G YodhUniversity of Pennsylvania, Department of Physics & Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, United States.

Funding

Training and DisseminationP41EB015893 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2012 to 2019
$11.3M
Diffuse Optics for Acute Stroke ManagementR01NS060653 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI YODH, ARJUN G. · 2008 to 2018
$5.5M
NIBIB NIH HHS P41 EB015893NIBIB NIH HHS P41-EB015893NINDS NIH HHS R01 NS060653NINDS NIH HHS R01-NS060653
6 · The paper itself

Abstract

We investigate and assess the utility of a simple scheme for continuous absolute blood flow monitoring based on diffuse correlation spectroscopy (DCS). The scheme calibrates DCS using venous-occlusion diffuse optical spectroscopy (VO-DOS) measurements of arm muscle tissue at a single time-point. A calibration coefficient (γ) for the arm is determined, permitting conversion of DCS blood flow indices to absolute blood flow units, and a study of healthy adults (N=10) is carried out to ascertain the variability of γ. The average DCS calibration coefficient for the right (i.e., dominant) arm was γ=(1.24±0.15)×10(8) (mL·100  mL(−1)·min(−1))/(cm(2)/s). However, variability can be significant and is apparent in our site-to-site and day-to-day repeated measurements. The peak hyperemic blood flow overshoot relative to baseline resting flow was also studied following arm-cuff ischemia; excellent agreement between VO-DOS and DCS was found (R(2)=0.95, slope=0.94±0.07, mean difference=−0.10±0.45). Finally, we show that incorporation of subject-specific absolute optical properties significantly improves blood flow calibration accuracy.

Indexed as

Regional Blood FlowAdultCalibrationFemaleHealthy VolunteersHemodynamicsHumansIschemiaMaleMuscle, SkeletalOptics and PhotonicsOxygen ConsumptionReproducibility of ResultsSpectrophotometrySpectroscopy, Near-Infrared

Identifiers

PMID26720870
PMCPMC4688416

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.