Evidence map›Paper›PMID 26720837›Full record

ArticlePloS one2015

Vessel Wall Inflammation of Takayasu Arteritis Detected by Contrast-Enhanced Magnetic Resonance Imaging: Association with Disease Distribution and Activity.

Yoko Kato, Masahiro Terashima, Hirokazu Ohigashi, Daisuke Tezuka, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. ACR Appropriateness Criteria® Noncerebral Vasculitis.Journal of the American College of Radiology : JACR · 2021
    Guideline
  2. Trial
  3. Management of Takayasu Arteritis - A 2026 Update.Current rheumatology reports · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Childhood-onset Takayasu Arteritis.European journal of rheumatology · 2020
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Delayed Vasospasm after Aneurysmal Subarachnoid Hemorrhage in Behcet Syndrome.Journal of cerebrovascular and endovascular neurosurgery · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yoko KatoDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Masahiro TerashimaCardiovascular Imaging Clinic, Tokyo, Japan.
Hirokazu OhigashiDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Daisuke TezukaDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Takashi AshikagaDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Kenzo HiraoDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Mitsuaki IsobeDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe assessment of the distribution and activity of vessel wall inflammation is clinically important in patients with Takayasu arteritis. Magnetic resonance imaging (MRI) is a useful tool, but the clinical utility of late gadolinium enhancement (LGE) in Takayasu arteritis has yet to be determined. The aim of the present study was to evaluate the utility of LGE in assessing vessel wall inflammation and disease activity in Takayasu arteritis. METHODS AND

resultsWe enrolled 49 patients with Takayasu arteritis who had undergone 1.5 T MRI. Patients were divided into Active (n = 19) and Inactive disease (n = 30) groups. The distribution of vessel wall inflammation using angiography and LGE was assessed by qualitative analysis. In 79% and 63% of patients in Active and Inactive groups, respectively, greater distribution of vessel wall inflammation was observed with LGE than with conventional angiography. MRI values of pre- and post-contrast signal-to-noise ratios (SNR), SNR increment (post-SNR minus pre-SNR), pre- and post-contrast contrast-to-noise ratios (CNR), and CNR increment (post-CNR minus pre-CNR) were evaluated at arterial wall sites with the highest signal intensity using quantitative analysis of post-contrast LGE images. No statistically significant differences in MRI parameters were observed between Active and Inactive groups. Contrast-enhanced MRI was unable to accurately detect active disease.

conclusionContrast-enhanced MRI has utility in detecting the distribution of vessel wall inflammation but has less utility in assessing disease activity in Takayasu arteritis.

Indexed as

Contrast MediaImage EnhancementMagnetic Resonance ImagingAdultAortaFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance AngiographyMaleMiddle AgedObserver VariationRetrospective StudiesSignal-To-Noise RatioTakayasu ArteritisYoung AdultContrast Media

Identifiers

PMID26720837
PMCPMC4700986
OpenAlexW2221164950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.